"CD40LG" Related Products

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Recombinant Human CD40LG, HIgG1 Fc-tagged

Cat.No.: CD40LG-33H
Product Overview: The extracellular domain of human CD40L (NP_000065.1) (Met113-Leu261) is fused to the N-terminus of the Fc portion of human IgG1was expressed in CHO cell
Description: The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.?
Source: CHO cells
Species: Human
Tag: HIgG1 Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured in a cell proliferation assay using enriched human B cells in the presence of IL-4.
Molecular Mass: 46 KDa (monomer)
AA Sequence: Met113-Leu261
Endotoxin: <0.06 eu/μg as determined by lal>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: CD40LG CD40 ligand [ Homo sapiens ]
Official Symbol: CD40LG
Synonyms: CD40LG; CD40 ligand; HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome); CD40 antigen ligand; CD40L; CD154; gp39; hCD40L; hyper IgM syndrome; T B cell activating molecule; TNF related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; CD40-L; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; IGM; IMD3; HIGM1; T-BAM; TNFSF5;
Gene ID: 959
mRNA Refseq: NM_000074
Protein Refseq: NP_000065
MIM: 300386
UniProt ID: P29965
Chromosome Location: Xq26
Pathway: Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem;
Function: CD40 receptor binding; cytokine activity; tumor necrosis factor receptor binding;

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