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Recombinant Human OLIG2, GST-tagged

Cat.No. : OLIG2-38H
Product Overview : Recombinant Human OLIG2 was expressed as gst-tagged fusion protein by E.Coli and puri?ed by GSH-sepharose.
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Description : This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
Source : E.coli
Species : Human
Tag : GST
Storage : The protein is stored in PBS bu?er at -20 oC. Reepeated freeze-thaw cycles should be avoided.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : OLIG2 oligodendrocyte lineage transcription factor 2 [ Homo sapiens ]
Official Symbol : OLIG2
Synonyms : OLIG2; oligodendrocyte lineage transcription factor 2; oligodendrocyte transcription factor 2; protein kinase C-binding protein 2; class B basic helix-loop-helix protein 1; class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; basic domain, helix-loop-helix protein, class B, 1; oligodendrocyte-specific bHLH transcription factor 2; BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19
Gene ID : 10215
mRNA Refseq : NM_005806
Protein Refseq : NP_005797
MIM : 606386
UniProt ID : Q13516
Chromosome Location : 21q22.11
Pathway : Neural Crest Differentiation
Function : DNA binding; HMG box domain binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; protein homodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does OLIG2 (Oligodendrocyte Transcription Factor 2) regulate the development and maturation of oligodendrocytes? 09/23/2022

OLIG2 is essential for the development and maturation of oligodendrocytes, which form myelin in the nervous system.

What is the impact of OLIG2 on the pathogenesis of gliomas and other brain tumors? 02/03/2021

OLIG2 is implicated in the development of gliomas, influencing tumor cell differentiation and growth.

What role does OLIG2 play in neural stem cell differentiation, particularly in the central nervous system? 06/05/2020

OLIG2 plays a crucial role in directing neural stem cells to differentiate into oligodendrocytes and neurons in the CNS.

How does OLIG2 influence neuronal and glial cell interactions during brain development? 12/11/2019

OLIG2 affects interactions between neurons and glial cells, essential for proper brain development.

How do alterations in OLIG2 expression or function affect neurodevelopmental disorders? 06/05/2019

Changes in OLIG2 can lead to neurodevelopmental disorders due to altered brain cell development and function.

How does OLIG2 contribute to the repair and regeneration of myelin in demyelinating diseases? 04/21/2018

OLIG2 contributes to myelin repair and regeneration, crucial in demyelinating diseases like multiple sclerosis.

What are the mechanisms by which OLIG2 modulates gene expression in neurodevelopmental processes? 01/09/2018

OLIG2 modulates gene expression, guiding key neurodevelopmental processes and cell fate decisions.

Customer Reviews (3)

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Reviews
01/24/2019

    Swift protein sequencing, invaluable for protein identification.

    07/05/2018

      Consistent western blot results, a lab necessity for us.

      05/26/2018

        Great protein crystallization service, vital for structural biology studies.

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