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Recombinant Swine IL21

Cat.No. : IL21-103S
Product Overview : Swine IL-21 was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
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Description : IL-21 is a member of the type I cytokine family, which includes IL-2 and IL-15. IL-21 signals through the common gamma-chain and a unique IL-21 receptor. The IL-21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL-21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL-21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity.
Source : Yeast
Species : Swine
Form : Lyophilized without carrier protein.
Molecular Mass : Swine IL-21 has a predicted molecular weight of 15.0 kDa.
AA Sequence : HKSSFQGQDR LLIRLRQLID TVDQLKNYVH DLDPELLPAP EDVQRHCEQS AFSCFQKVEL KSANTGDNEK IINVLIKQLK RKLPPTNAGR RQKHGLTCPT CDSYEKKPIK EFLERLKSLI QKMIHQHLS
Purity : >95% as visualized by SDS-PAGE analysis.
Applications : The Swine IL-21 protein can be used in cell culture, as an IL-21 ELISA Standard, and as a Western Blot Control.
Storage : Stable for up to twelve months from date of receipt at -20?C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20?C. Avoid repeated freeze/thaw cycles.
Reconstitution : Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In which types of cancer has IL21 protein shown promising results? 02/17/2023

IL21 has demonstrated efficacy in preclinical and clinical studies for various cancers, including melanoma, renal cell carcinoma, and lymphoma.

Are there any side effects associated with IL21 therapy? 11/12/2021

Common side effects may include fatigue, fever, and flu-like symptoms. However, the severity and type of side effects can vary among individuals.

Can IL21 be used as a standalone treatment for cancer? 09/17/2021

IL21 is often investigated in combination with other cancer therapies to enhance its effectiveness, and it has shown promise in combination treatments.

Are there any ongoing clinical trials exploring the use of IL21 in autoimmune conditions? 03/04/2020

Yes, several clinical trials are investigating the efficacy and safety of IL21 in autoimmune diseases, such as rheumatoid arthritis and lupus.

How does IL21 influence the development of memory T cells? 10/29/2018

IL21 promotes the differentiation and survival of memory T cells, contributing to the long-term immune response against pathogens.

Customer Reviews (3)

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Reviews
08/19/2022

    With the IL21 protein at hand, I am excited to embark on my scientific journey with confidence and optimism.

    01/30/2022

      I am confident that incorporating the IL21 protein into my research will yield accurate and reliable results, enabling deeper insights into cellular processes

      04/23/2019

        Their expertise and guidance will undoubtedly prove valuable in overcoming hurdles and maximizing the potential of this protein in my research endeavors.

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