Active Recombinant Human IGFBP1 Protein
Cat.No. : | IGFBP1-79H |
Product Overview : | Recombinant human IGFBP1 protein (Ala26-Asn259) without tag was expressed in mouse myeloma cell line. |
- Specification
- Gene Information
- Related Products
Description : | This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. |
Source : | Mammalian cells |
Species : | Human |
Bio-activity : | Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF‑7 human breast cancer cells. The ED50 for this effect is typically 0.1-0.6 μg/mL in the presence of 6 ng/mL recombinant human IGF-I. |
Molecular Mass : | 25 kDa |
N-terminal Sequence Analysis : | Ala26 |
Endotoxin : | <0.10 EU per 1 μg of the protein by the LAL method. |
Purity : | >97%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
Gene Name : | IGFBP1 insulin like growth factor binding protein 1 [ Homo sapiens (human) ] |
Official Symbol : | IGFBP1 |
Synonyms : | alpha-pregnancy-associated endometrial globulin; amniotic fluid binding protein; binding protein-25; binding protein-26; binding protein-28; growth hormone independent-binding protein; hIGFBP-1; IBP1; IBP-1; IGF-binding protein 1; IGFBP1; IGFBP-1; IGF-BP25; insulin-like growth factor binding protein 1; insulin-like growth factor-binding protein 1; Placental protein 12; PP12AFBP |
Gene ID : | 3484 |
mRNA Refseq : | NM_000596 |
Protein Refseq : | NP_000587 |
MIM : | 146730 |
UniProt ID : | P08833 |
Products Types
◆ Recombinant Protein | ||
IGFBP1-03H | Active Recombinant Human IGFBP-1 Protein (26-259aa) | +Inquiry |
IGFBP1-2663R | Recombinant Rat IGFBP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IGFBP1-0013H | Recombinant Human IGFBP1 Protein | +Inquiry |
IGFBP1-4428H | Recombinant Human IGFBP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IGFBP1-4467M | Recombinant Mouse IGFBP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
IGFBP1-612H | Native Human Insulin-like Growth Factor Binding Protein 1 | +Inquiry |
◆ Lysates | ||
IGFBP1-1482CCL | Recombinant Cynomolgus IGFBP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIGFBP1 influences the progression of certain cancers, particularly those sensitive to hormonal regulation.
Changes in IGFBP1 expression contribute to the aging process and the development of age-related diseases.
IGFBP1 is important for fetal growth and development, regulating growth factor activity during pregnancy.
IGFBP1 affects muscle growth and regeneration, playing a role in conditions involving muscle wasting.
IGFBP1 impacts cardiovascular health, influencing factors like blood vessel growth and atherosclerosis development.
IGFBP1 plays a crucial role in glucose metabolism and insulin sensitivity, impacting overall metabolic health.
IGFBP1 modulates the availability and activity of IGFs, affecting growth and metabolic functions in various tissues.
Customer Reviews (3)
Write a reviewPrecise antibody validation, enhances immunoprecipitation studies.
Efficient protein purification, delivers high yield and purity.
Dependable expertise in protein engineering, unmatched quality.
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