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Recombinant Human ARNT, MYC/DDK-tagged

Cat.No.: ARNT-18H
Product Overview: Recombinant Human ARNT, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description: This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants.
Source: HEK293 cells
Species: Human
Tag: MYC/DDK
Molecular Mass: 86.5 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name: ARNT aryl hydrocarbon receptor nuclear translocator [ Homo sapiens (human) ]
Official Symbol: ARNT
Synonyms: ARNT; aryl hydrocarbon receptor nuclear translocator; bHLHe2; HIF 1beta; dioxin receptor, nuclear translocator; class E basic helix-loop-helix protein 2; hypoxia-inducible factor 1, beta subunit; HIF1B; TANGO; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta
Gene ID: 405
mRNA Refseq: NM_001668
Protein Refseq: NP_001659
MIM: 126110
UniProt ID: P27540
Chromosome Location: 1q21
Pathway: AhR pathway; Cellular response to hypoxia; HIF-1 signaling pathway
Function: contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; aryl hydrocarbon receptor activity; enhancer binding

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