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Recombinant Human PTPRN cell lysate

Cat.No.: PTPRN-1440HCL
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
Species: Human
Size: 100 ul
Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications: Western Blot;
Gene Name: PTPRN protein tyrosine phosphatase, receptor type, N [ Homo sapiens ]
Official Symbol: PTPRN
Synonyms: PTPRN; protein tyrosine phosphatase, receptor type, N; receptor-type tyrosine-protein phosphatase-like N; IA 2; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP; FLJ16131;
Gene ID: 5798
mRNA Refseq: NM_001199763
Protein Refseq: NP_001186692
MIM: 601773
UniProt ID: Q16849
Chromosome Location: 2q35-q36.1
Pathway: Type I diabetes mellitus, organism-specific biosystem; Type I diabetes mellitus, conserved biosystem;
Function: GTPase binding; hydrolase activity; phosphatase activity; protein binding; protein tyrosine phosphatase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase activity;

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