Recombinant Human TYMS cell lysate
Cat.No. : | TYMS-1868HCL |
- Specification
- Gene Information
- Related Products
Description : | Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | TYMS thymidylate synthetase [ Homo sapiens ] |
Official Symbol : | TYMS |
Synonyms : | TYMS; thymidylate synthetase; TS; thymidylate synthase; HsT422; TMS; Tsase; TSase; HST422; MGC88736; |
Gene ID : | 7298 |
mRNA Refseq : | NM_001071 |
Protein Refseq : | NP_001062 |
MIM : | 188350 |
UniProt ID : | P04818 |
Chromosome Location : | 18p11.31-p11.21 |
Pathway : | Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; E2F mediated regulation of DNA replication, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; G1/S Transition, organism-specific biosystem; G1/S-Specific Transcription, organism-specific biosystem; |
Function : | cofactor binding; folic acid binding; methyltransferase activity; nucleotide binding; thymidylate synthase activity; thymidylate synthase activity; transferase activity; |
Products Types
◆ Recombinant Protein | ||
TYMS-616H | Recombinant Human TYMS Protein, His-tagged | +Inquiry |
TYMS-6037R | Recombinant Rat TYMS Protein, His (Fc)-Avi-tagged | +Inquiry |
TYMS-9797M | Recombinant Mouse TYMS Protein, His (Fc)-Avi-tagged | +Inquiry |
Tyms-6756M | Recombinant Mouse Tyms Protein, Myc/DDK-tagged | +Inquiry |
TYMS-684H | Recombinant Human TYMS protein, MYC/DDK-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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