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Recombinant Human PDCD1LG2, His-tagged

Cat.No.: PDCD1LG2-168H
Product Overview: Recombinant Human B7-DC /PD-L2 /CD273 Protein (rh B7-DC / PD-L2 / CD273) Leu 20 - Pro 219 (Accession # AAI13679) was produced in human 293 cells (HEK293).
Description: Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Source: HEK293
Species: Human
Tag: His
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Bio-activity: Measured by its binding ability in a functional ELISA.Immobilized rh B7-DC / PD-L2 / CD273 at 1 μg/mL (100 μl/well) can bind rhPDCD-1 with a linear range of 15 - 500 ng/ml.
Molecular Mass: rh B7-DC / PD-L2 / CD273, fused with polyhistidine tag at the C-terminus, has a calculated MW of 23.4 kDa. The predicted N-terminus is Leu 20. DTT-reduced Protein migrates as 35-48 kDa due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the rh B7-DC / PD-L2 / CD273 by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Reconstitution: See Certificate of Analysis for reconstitution instructions and specific concentrations.
Gene Name: PDCD1LG2 programmed cell death 1 ligand 2 [ Homo sapiens ]
Official Symbol: PDCD1LG2
Synonyms: PDCD1LG2; programmed cell death 1 ligand 2; B7 dendritic cell molecule; B7 DC; bA574F11.2; Btdc; CD273; PD L2; PDL2; B7-DC; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; programmed death ligand 2; B7DC; PD-L2; PDCD1L2; MGC142238; MGC142240;
Gene ID: 80380
mRNA Refseq: NM_025239
Protein Refseq: NP_079515
MIM: 605723
UniProt ID: Q9BQ51
Chromosome Location: 9p24.2
Pathway: Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem;
Function: molecular_function; protein tyrosine phosphatase activity; receptor activity;

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