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Recombinant Human PLA2G1B protein, His-tagged

Cat.No. : PLA2G1B-171H
Product Overview : Recombinant Human PLA2G1B (Ala23-Ser148) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
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Description : Phosphatidylcholine 2-acylhydrolase 1B (PLA2G1B) is also known as Phospholipase A2 (PLA2), PLA2A, PPLA2, which belongs to the phospholipase A2 family. PLA2G1B is activated by trypsin cleavage in the duodenum and can also be activated by thrombin or autocatalytically. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Ala23
Form : Lyophilized from 0.22 μm filtered solution in 20 mM Hepes, 150 mM NaCl, pH7.0, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 15.0 kDa. The protein migrates as 19 kDa under reducing (R) condition (SDS-PAGE).
Protein length : Ala23-Ser148
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : PLA2G1B
Official Symbol : PLA2G1B
Synonyms : PLA2G1B; phospholipase A2, group IB (pancreas); PLA2, PLA2A, PPLA2; phospholipase A2; group IB phospholipase A2; phosphatidylcholine 2-acylhydrolase 1B; PLA2; PLA2A; PPLA2; MGC119834; MGC119835
Gene ID : 5319
mRNA Refseq : NM_000928
Protein Refseq : NP_000919
MIM : 172410
UniProt ID : P04054

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is PLA2G1B involved in cardiovascular diseases? 07/01/2020

PLA2G1B is associated with atherosclerosis and other cardiovascular conditions due to its involvement in lipid metabolism and inflammation.

Are there potential neuroprotective effects of modulating PLA2G1B activity? 12/19/2019

Modulating PLA2G1B activity could be explored for potential neuroprotective effects, given its involvement in processes related to neuroinflammation.

In what diseases is PLA2G1B dysregulation observed? 07/30/2018

Dysregulation of PLA2G1B has been linked to inflammatory disorders, cardiovascular diseases, and certain cancers.

Can PLA2G1B be a therapeutic target for inflammatory conditions? 11/10/2017

Yes, targeting PLA2G1B may be a potential therapeutic strategy for inflammatory diseases, as it plays a role in the production of inflammatory mediators.

Can PLA2G1B inhibitors be used for treating cancer? 09/18/2017

Inhibiting PLA2G1B may be explored as a therapeutic approach in cancer treatment by disrupting lipid metabolism and inhibiting cancer cell proliferation.

Customer Reviews (3)

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Reviews
03/12/2020

    Its exceptional purity and stability make it an ideal choice for a wide range of applications, ensuring reliable and reproducible results.

    10/16/2017

      The PLA2G1B protein comes highly recommended for its exceptional performance in various research applications.

      01/09/2016

        Its unique characteristics contribute to obtaining clear and detailed structural information, allowing researchers to gain insights into protein interactions and conformational changes.

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