"CD40" Related Products

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Recombinant Human CD40 protein, His/Fc-tagged, Biotinylated

Cat.No.: CD40-202H
Product Overview: Recombinant Human CD40(Leu 25 - Ser 645) fused with His and human IgG1 Fc fragment tag at C-terminal was expressed in HEK293, was enzymatically single-point biotinlabeled at C-terminus to retain its native conformational structure and bioactivity.
Source: HEK293
Species: Human
Tag: His/Fc
Predicted N Terminal: Glu 21
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Bio-activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD40 Ligand, His Tag at 5 μg/mL ( 100 μl/well ) can bind Biotinylated Human CD40, His Tag & Fc Tag with a linear range of 0.2-1μg/mL.
Molecular Mass: Has a calculated MW of 48 kDa. DTT-reduced Protein migrates as 55-65 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the Biotinylated Human CD40, His Tag & Fc tag by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Applications: Has been used successfully for ELISA, western blotting, inhibition assay, pull-down, SPR, FACS, and affinity purification, together with anti-biotin antibody, streptavidin or avidin-conjugated probes.
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade).
Gene Name: CD40 CD40 molecule, TNF receptor superfamily member 5 [ Homo sapiens ]
Official Symbol: CD40
Synonyms: CD40; CD40 molecule, TNF receptor superfamily member 5; TNFRSF5, tumor necrosis factor receptor superfamily, member 5; tumor necrosis factor receptor superfamily member 5; Bp50; p50; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; B-cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily, member 5; nerve growth factor receptor-related B-lymphocyte activation molecule; CDW40; TNFRSF5; MGC9013;
Gene ID: 958
mRNA Refseq: NM_001250
Protein Refseq: NP_001241
MIM: 109535
UniProt ID: P25942
Chromosome Location: 20q12-q13.2
Pathway: Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem;
Function: enzyme binding; protein binding; receptor activity; signal transducer activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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