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Recombinant Human PHLPP2, GST-tagged

Cat.No. : PHLPP2-1615H
Product Overview : Recombinant human PHLPP2 (766-1043) was expressed in E. coli cells using an N-terminal GST tag.
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  • Gene Information
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Description : PHLPP2 or PH domain and leucine rich repeat protein phosphatase 2 is the important regulators of Akt serine-threonine kinases and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 differentially regulated AKT signaling by selectively dephosphorylating the hydrophobic motifs of AKT2 or AKT3. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells.
Source : E.coli
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~ 56 kDa
Protein length : 766-1043
Purity : >95%
Applications : Phosphatase Assay; Western Blot
Stability : 1 yr at -70oC from date of shipment.
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ul
Gene Name : PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 [ Homo sapiens ]
Official Symbol : PHLPP2
Synonyms : PHLPP2; PH domain and leucine rich repeat protein phosphatase 2; PH domain and leucine rich repeat protein phosphatase like , PHLPPL; PH domain leucine-rich repeat-containing protein phosphatase 2; KIAA0931; PHLPPL
Gene ID : 23035
mRNA Refseq : NM_015020
Protein Refseq : NP_055835
MIM : 611066
UniProt ID : Q6ZVD8
Chromosome Location : 16q22.2
Pathway : Adaptive Immune System; DAP12 signaling; Downstream signaling events of B Cell Receptor (BCR); Downstream signaling of activated FGFR
Function : metal ion binding; protein serine/threonine phosphatase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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