Recombinant Human ERBB3, His-tagged, C13&N15 Labeled
Cat.No. : | ERBB3-196H |
Product Overview : | Recombinant Human ErbB-3 /HER3 MS Standard Protein, C13 and N15-labeled (ErbB-3 / HER3, Heavy Labeled) Ser 20 - Thr 643 (Accession # NP_001973.2) was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain >99% inc |
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- Gene Information
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Description : | ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Ser 20 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization. |
Molecular Mass : | ErbB-3 / HER3, Heavy Labeled is fused with polyhistidine tag at the C-terminus, and has a calculated MW of 71.5 kDa. The predicted N-terminus is Ser 20. DTT-reduced Protein migrates as 100-110 kDa in SDS-PAGE due to glycosylation.ErbB-3 / HER3, Heavy Lab |
Endotoxin : | Less than 1.0 EU per μg of the ErbB-3 / HER3, Heavy Labeled by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Applications : | MS Standard Protein |
Storage : | Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC). |
Gene Name : | ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homo sapiens ] |
Official Symbol : | ERBB3 |
Synonyms : | ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033; |
Gene ID : | 2065 |
mRNA Refseq : | NM_001005915 |
Protein Refseq : | NP_001005915 |
MIM : | 190151 |
UniProt ID : | P21860 |
Chromosome Location : | 12q13 |
Pathway : | Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Downregulation of ERRB2:ERBB3 signaling, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; ErbB receptor signaling network, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; |
Function : | ATP binding; growth factor binding; growth factor binding; nucleotide binding; protein binding; protein heterodimerization activity; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; NOT pr |
Products Types
◆ Recombinant Protein | ||
ERBB3-209H | Active Recombinant Human ERBB3(Met1-Thr643), His-tagged | +Inquiry |
ERBB3-68H | Recombinant Human ERBB3 Protein (ECD), His-tagged(C-ter) | +Inquiry |
ERBB3-44H | Active Recombinant Human ERBB3(Ser20-Thr643), Fc-tagged | +Inquiry |
Erbb3-43M | Recombinant Mouse Erbb3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ERBB3-28H | Active Recombinant Human ERBB3 Protein (Ser20-Gly538), C-6×His tagged | +Inquiry |
◆ Lysates | ||
ERBB3-430HCL | Recombinant Human ERBB3 cell lysate | +Inquiry |
ERBB3-1721RCL | Recombinant Rhesus ERBB3 cell lysate | +Inquiry |
ERBB3-939HCL | Recombinant Human ERBB3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPotential side effects may include skin rash, diarrhea, and cardiovascular issues, as seen with other drugs targeting the EGFR family.
ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.
ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.
Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.
ERBB3 overexpression is frequently observed in breast, ovarian, and gastric cancers, among others.
Customer Reviews (3)
Write a reviewTheir expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.
Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.
The ERBB3 protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.
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