Recombinant Human C1QC, MYC/DDK-tagged

• Cat.No.: C1QC-8142H
• Product Overview: Recombinant Human C1QC, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene.
• Source: HEK293 cells
• Species: Human
• Tag: MYC/DDK
• Molecular Mass: 22.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: C1QC complement component 1, q subcomponent, C chain [ Homo sapiens ]
• Official Symbol: C1QC
• Synonyms: C1QC; complement component 1, q subcomponent, C chain; C1QG, complement component 1, q subcomponent, gamma polypeptide; complement C1q subcomponent subunit C; AI385742; C1Q C; C1qc; C1QC_HUMAN; C1QG; Complement C1q subcomponent subunit C; Complement component 1, q subcomponent, C chain; complement component 1, q subcomponent, gamma polypeptide; OTTHUMP00000002932; OTTHUMP00000002933; OTTHUMP00000037922; complement component 1, q subcomponent, gamma polypeptide; C1QG; C1Q-C
• Gene ID: 714
• mRNA Refseq: NM_172369
• Protein Refseq: NP_758957
• MIM: 120575
• UniProt ID: P02747
• Chromosome Location: 1p36.11
• Pathway: Chagas disease (American trypanosomiasis); Complement Activation, Classical Pathway; Creation of C4 and C2 activators