Active Recombinant Human CD40LG
Cat.No. : | CD40LG-23H |
Product Overview : | Recombinant Human CD40 Ligand/CD40LG is produced by our E. coli expression system. The target protein is expressed with sequence (Met113-Leu261) of Human CD40LG. |
- Specification
- Gene Information
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Description : | CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2 μM filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Bio-activity : | < 100 ng/ml on> |
Endotoxin : | Less than 0.1 EU/μg. |
Purity : | Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at< -20°c, though stable at room temperature for 3>Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at< -20°c for 3> |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 1X PBS.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | CD40LG CD40 ligand [ Homo sapiens ] |
Official Symbol : | CD40LG |
Synonyms : | CD40LG; CD40 ligand; HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome); CD40 antigen ligand; CD40L; CD154; gp39; hCD40L; hyper IgM syndrome; T B cell activating molecule; TNF related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; CD40-L; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; IGM; IMD3; HIGM1; T-BAM; TNFSF5; |
Gene ID : | 959 |
mRNA Refseq : | NM_000074 |
Protein Refseq : | NP_000065 |
MIM : | 300386 |
UniProt ID : | P29965 |
Chromosome Location : | Xq26 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; |
Function : | CD40 receptor binding; cytokine activity; tumor necrosis factor receptor binding; |
Products Types
◆ Recombinant Protein | ||
CD40LG-11H | Active Recombinant Human CD40LG Protein (116-261), N-FLAG tagged, Biotinylated | +Inquiry |
CD40LG-38H | Active Recombinant Human CD40LG Protein | +Inquiry |
CD40LG-197H | Recombinant Human CD40LG Protein, C-His-tagged | +Inquiry |
CD40LG-392R | Recombinant Rabbit CD40LG Protein (113-261 aa), His-tagged | +Inquiry |
CD40LG-0818H | Recombinant Human CD40LG Protein, GST-Tagged | +Inquiry |
◆ Lysates | ||
CD40LG-1548MCL | Recombinant Mouse CD40LG cell lysate | +Inquiry |
CD40LG-1965HCL | Recombinant Human CD40LG cell lysate | +Inquiry |
CD40LG-001CCL | Recombinant Canine CD40LG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (5)
Ask a questionYes, there are clinical trials investigating the modulation of CD40LG in autoimmune diseases, exploring its potential role in regulating immune responses that contribute to autoimmunity.
Yes, research suggests that CD40LG modulation might be a viable strategy in the development of treatments for infectious diseases by enhancing immune responses.
The interaction between CD40LG and CD40 is crucial for the activation of B cells, leading to the production of antibodies and the development of an effective immune response.
CD40LG is involved in modulating inflammatory responses by influencing the activation and function of immune cells, contributing to the regulation of the immune system.
CD40LG is being investigated as an adjuvant in vaccine development, aiming to enhance the immune response and improve the efficacy of vaccines against various diseases.
Customer Reviews (3)
Write a reviewThe reliable performance of the CD40LG protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.
Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.
Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.
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