Active Recombinant Human TGFB2 Protein

• Cat.No.: TGFB2-104H
• Product Overview: The mature recombinant human TGF-beta 2 protein consists of 112 amino acids (303-414) without tag was expressed in E. coli.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing.
• Source: E. coli
• Species: Human
• Bio-activity: Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. The ED50 for this effect is 0.025-0.25 ng/mL.
• Molecular Mass: 12.7 kDa
• Product-Related Proteins: 303-414
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: TGFB2 transforming growth factor beta 2 [ Homo sapiens (human) ]
• Official Symbol: TGFB2
• Synonyms: TGFB2; transforming growth factor beta 2; LDS4; G-TSF; TGF-beta2; transforming growth factor beta-2 proprotein; Names; BSC-1 cell growth inhibitor; cetermin; glioblastoma-derived T-cell suppressor factor; polyergin; prepro-transforming growth factor beta-2
• Gene ID: 7042
• mRNA Refseq: NM_003238
• Protein Refseq: NP_003229
• MIM: 190220
• UniProt ID: P61812