Thyroxine-binding globulin Reference standard

• Cat.No.: SERPINA7-196H
• Product Overview: The content of the reference standard is that, 30IU per ampoule is equivalent to the nominal ampoule content of 30 micrograms thyroxine-binding globulin, as estimated by physicochemical analyses. For further details of this Standard and its collaborative study see Bristow et al (1993).

Specification

• Species: Human
• Enzyme Unit: 30 INTERNATIONAL UNITS per ampoule, by definition.
• Usage: For practical purposes each ampoule contains the same quantity of TBG. The entire contents of each ampoule should be completely dissolved in an accurately measured amount of buffer solution. No attempt should be made to weigh out portions of the freeze-dried powder. The reconstitution buffer should contain carrier protein. For economy in use, it is recommended that the solution, without further dilution, is sub-divided into several small containers and stored at -30 °C or below. To maintain full activity of such stored aliquots, it is suggested that the solution of ampoule contents, its subdivision and its freezing (using CO2/ethanol or liquid N2) is done rapidly. A dilute solution prepared for use in an assay should be kept cool (eg. 4 °C) and should contain not less than 0.1% w/v carrier protein (free of proteolytic enzymes). Repeated freezing and thawing should be avoided. The material has not been sterilized and the ampoules contain no bacteriostat.
• Notes: This preparation is not for administration to humans. The preparation contains material of human origin, and either the final product or the source materials, from which it is derived, have been tested and found negative for HBsAg, anti-HIV and HCV RNA. However, as with all materials of human origin, the preparation cannot be assumed to be free from infectious agents. The container and its contents should be used and discarded according to your own laboratory procedures. Such procedures probably will include the wearing of protective gloves and avoiding the generation of aerosols. Care should be exercised in opening the container to avoid cuts.
• Storage: Unopened ampoules should be stored at -20°C. Please note: because of the inherent stability of lyophilized material, Creative Biomart may ship these materials at ambient temperature.

Gene Information

• Gene Name: SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 [ Homo sapiens ];
• Official Symbol: SERPINA7
• Synonyms: TBG; thyroxine-binding globulin; serpin A7; T4-binding globulin; thyroxin-binding globulin; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
• Gene ID: 6906
• mRNA Refseq: NM_000354
• Protein Refseq: NP_000345
• MIM: 314200
• UniProt ID: P05543
• Chromosome Location: Xq22.2
• Function: hormone binding; serine-type endopeptidase inhibitor activity