Recombinant Human Thyroid hormone receptor beta, GST-tagged

• Cat.No.: THRB-110H
• Product Overview: Recombinant Human Thyroid hormone receptor beta ligand-binding domain (THRB-LBD) consists of a 218 a.a. GST tag, a 13 a.a. flexible linker and a 260 a.a. THRB-LBD, Acc# AAI06930.1, amino acids 202-461. GST tagged THRB-LBD was expressed in baculovirus-infected insect cells and purified using affinity chromatography.

Specification

• Description: Thyroid hormone receptor beta (TR-beta or THRB) is also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2).
• Source: Sf9 insect cells
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCl pH 8.0, 150 mM NaCl, 0.5 mM EDTA, 3 mM Dithiothreitol, 7 mM reduced glutathione, 20% glycerol.
• Purity: >90%
• Applications: Ligand binding and coactivator peptide recruitment assays.
• Storage: Immediately store at -80℃. Avoid freeze-thaw cycles.While working, please keep sample on ice.

Gene Information

• Gene Name: THRB thyroid hormone receptor, beta [ Homo sapiens ]
• Official Symbol: THRB
• Synonyms: THRB; thyroid hormone receptor, beta; ERBA2, pituitary resistance to thyroid hormone , PRTH, thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v erb a) oncogene homolog 2) , thyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian); thyroid hormone receptor beta; avian erythroblastic leukemia viral (v erb a) oncogene homolog 2; ERBA BETA; generalized resistance to thyroid hormone; GRTH; NR1A2; oncogene ERBA2; THR1; THRB1; THRB2; thyroid hormone receptor beta 1; nuclear receptor subfamily 1 group A member 2; thyroid hormone nuclear receptor beta variant 1; thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); PRTH; ERBA2; C-ERBA-2; C-ERBA-BETA; MGC126109; MGC126110
• Gene ID: 7068
• mRNA Refseq: NM_000461
• Protein Refseq: NP_000452
• MIM: 190160
• UniProt ID: P10828
• Chromosome Location: 3p24.2
• Pathway: Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem
• Function: DNA binding; enzyme binding; metal ion binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; thyroid hormone receptor activity; transcription corepressor activity; zinc ion binding