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Recombinant Human NR1H4, GST-tagged

Cat.No. : NR1H4-117H
Product Overview : Recombinant Human GST-tagged Farnesoid X receptor ligand-binding domain (FXR-LBD) consists of a 218 a.a. GST tag, a 13 a.a. flexible linker and a 246 a.a. FXR-LBD, Acc# AAI30574.1, amino acids 231-476, was expressed in baculovirus-infected insect cells and purified using affinity chromatography.
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Description : Farnesoid X receptor (FXR) is also known as nuclear receptor subfamily 1, group H, member 4 (NR1H4).
Source : Sf9 insect cells
Species : Human
Tag : GST
Form : 50 mM Tris-HCl pH 8.0, 150 mM NaCl, 0.5 mM EDTA, 3 mM Dithiothreitol, 7 mM reduced glutathione, 20% glycerol.
Purity : >90%
Applications : Ligand binding and coactivator peptide recruitment assays.
Storage : Immediately store at -80℃. Avoid freeze-thaw cycles.While working, please keep sample on ice.
Gene Name : NR1H4 nuclear receptor subfamily 1, group H, member 4 [ Homo sapiens ]
Official Symbol : NR1H4
Synonyms : NR1H4; nuclear receptor subfamily 1, group H, member 4; bile acid receptor; FXR; HRR 1; HRR1; RIP14; farnesol receptor HRR-1; RXR-interacting protein 14; farnesoid X nuclear receptor; farnesoid X-activated receptor; retinoid X receptor-interacting protein 14; BAR; HRR-1; MGC163445;
Gene ID : 9971
mRNA Refseq : NM_001206977
Protein Refseq : NP_001193906
MIM : 603826
UniProt ID : Q96RI1
Chromosome Location : 12q23.1
Pathway : Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem; RXR and RAR heterodimerization with other nuclear receptor, organism-specific biosystem;
Function : RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; bile acid binding; bile acid binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; ligand-dependent nuclear receptor binding; metal ion binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; steroid hormone receptor activity; thyroid hormone receptor activity; transcription coactivator activity; transcription corepressor activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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