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Active Recombinant Mouse Tnfsf9, His-tagged

Cat.No. : Tnfsf9-132M
Product Overview : A DNA sequence encoding the extracellular domain (Arg 104-Glu 309) of mouse TNFSF9 precursor was expressed with a N-terminal polyhistidine tag.
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Description : 4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
Source : Human Cells
Species : Mouse
Tag : His
Predicted N Terminal : His
Form : Lyophilized from sterile PBS, pH 7.4
Bio-activity : Measured by its binding ability in a functional ELISA . Immobilized recombinant mouse 4-1BB Ligand at 20 μg/ml (100ul/well) can bind human 4-1BB with a linear range of 15.6-500 ng/ml .
Molecular Mass : The secreted recombinant mouse TNFSF9 consists of 222 amino acids and has a calculated molecular mass of 25 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 40-45 kDa protein in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 97 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70?
Storage : Store it under sterile conditions at -20? to -80?. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 [ Mus musculus (house mouse) ]
Official Symbol : Tnfsf9
Synonyms : Tnfsf9; tumor necrosis factor (ligand) superfamily, member 9; Ly63l; 4-1BBL; Cd137l; 4-1BB-L; AI848817; tumor necrosis factor ligand superfamily member 9; 4-1BB ligand
Gene ID : 21950
mRNA Refseq : NM_009404
Protein Refseq : NP_033430
UniProt ID : P41274
Chromosome Location : 17 D; 17
Pathway : Cytokine-cytokine receptor interaction
Function : cytokine activity; receptor binding; tumor necrosis factor receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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