Recombinant Human KLOTHO, His-tagged
Cat.No. : | KL-47H |
Product Overview : | Recombinant Human KL is produced in CHO cells and fused with a C-terminal 6xHis Tag. The Klotho His Tagged Fusion Protein is 59.5kDa protein containing a total of 522 amino acid residues and purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. |
Source : | CHO |
Species : | Human |
Tag : | His |
Form : | Klotho Human recombinant was filtered (0.4µm) and lyophilized from 0.5 mg/ml in 0.08M phosphate buffer and 0.1M NaCl, pH 7.2. |
Molecular Mass : | 59.5kDa |
AA Sequence : | EPGDGAQTWA RFSRPPAPEA AGLFQGTFPD GFLWAVGSAA YQTEGGWQQH GKGASIWDTF THHPLAPPGD SRNASLPLGA PSPLQPATGD VASDSYNNVF RDTEALRELG VTHYRFSISW ARVLPNGSAG VPNREGLRYY RRLLERLREL GVQPVVTLYH WDLPQRLQDA YGGWANRALA DHFRDYAELC FRHFGGQVKY WITIDNPYVV AWHGYATGRL APGIRGSPRL GYLVAHNLLL AHAKVWHLYN TSFRPTQGGQ VSIALSSHWI NPRRMTDHSI KECQKSLDFV LGWFAKPVFI DGDYPESMKN NLSSILPDFT ESEKKFIKGT ADFFALCFGP TLSFQLLDPH MKFRQLESPN LRQLLSWIDL EFNHPQIFIV ENGWFVSGTT KRDDAKYMYY LKKFIMETLK AIKLDGVDVI GYTAWSLMDG FEWHRGYSIR RGLFYVDFLS QDKMLLPKSS ALFYQKLIEK NGFPPLPENQ PLEGTFPCDF AWGVVDNYIQ VSQLTKPISS LTKPYHHHHH HH. |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Applications : | ELISA, Immunoassays, Western blotting. |
Stability : | Store lyophilized Klotho Human recombinant at -20°C. Aliquot Klotho after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
Reconstitution : | It is recommended to add to Klothodeionized water to prepare a working stock solution of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter Klothoby an appropriate sterile filter before using it in the cell culture. |
Gene Name : | KL klotho [ Homo sapiens (human) ] |
Official Symbol : | KL |
Synonyms : | KL; klotho; EC 3.2.1.31; Klotho peptide; OTTHUMP00000018796; NP_004786.2 |
Gene ID : | 9365 |
mRNA Refseq : | NM_004795 |
Protein Refseq : | NP_004786 |
MIM : | 604824 |
UniProt ID : | Q9UEF7 |
Chromosome Location : | 13q12 |
Pathway : | Adaptive Immune System; Constitutive PI3K/AKT Signaling in Cancer; Downstream signal transduction |
Function : | beta-glucosidase activity; beta-glucuronidase activity; fibroblast growth factor binding |
Products Types
◆ Recombinant Protein | ||
KL-3220H | Recombinant Human KL Protein, His (Fc)-Avi-tagged | +Inquiry |
KL-4828M | Recombinant Mouse KL Protein, His (Fc)-Avi-tagged | +Inquiry |
Kl-1714R | Recombinant Rat Kl Protein, His-tagged | +Inquiry |
KL-2922R | Recombinant Rat KL Protein, His (Fc)-Avi-tagged | +Inquiry |
KL-1071H | Recombinant Human KL Protein, His&SUMO-tagged | +Inquiry |
◆ Lysates | ||
KL-4936HCL | Recombinant Human KL 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionKL protein may have a neuroprotective role and is being studied for its potential in preserving cognitive function and preventing neurodegenerative diseases.
Currently, there are no FDA-approved KL protein-based therapies, but research in this area is ongoing.
While research suggests a connection between KL protein and aging, it is not yet clear if KL protein supplementation can effectively slow down the aging process in humans.
KL protein levels can be measured in blood and urine samples using various laboratory techniques.
Yes, several clinical trials are investigating the potential therapeutic benefits of KL protein supplementation in kidney disease and other disorders.
Customer Reviews (3)
Write a reviewThe KL protein's reliability and ease of use have made it an essential component of my structural investigations.
Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.
Furthermore, the KL protein has demonstrated great utility in protein electron microscopy structure analysis.
Ask a Question for All KL Products
Required fields are marked with *
My Review for All KL Products
Required fields are marked with *
Inquiry Basket