Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human KLOTHO, His-tagged

Cat.No. : KL-47H
Product Overview : Recombinant Human KL is produced in CHO cells and fused with a C-terminal 6xHis Tag. The Klotho His Tagged Fusion Protein is 59.5kDa protein containing a total of 522 amino acid residues and purified by proprietary chromatographic techniques.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
Source : CHO
Species : Human
Tag : His
Form : Klotho Human recombinant was filtered (0.4µm) and lyophilized from 0.5 mg/ml in 0.08M phosphate buffer and 0.1M NaCl, pH 7.2.
Molecular Mass : 59.5kDa
AA Sequence : EPGDGAQTWA RFSRPPAPEA AGLFQGTFPD GFLWAVGSAA YQTEGGWQQH GKGASIWDTF THHPLAPPGD SRNASLPLGA PSPLQPATGD VASDSYNNVF RDTEALRELG VTHYRFSISW ARVLPNGSAG VPNREGLRYY RRLLERLREL GVQPVVTLYH WDLPQRLQDA YGGWANRALA DHFRDYAELC FRHFGGQVKY WITIDNPYVV AWHGYATGRL APGIRGSPRL GYLVAHNLLL AHAKVWHLYN TSFRPTQGGQ VSIALSSHWI NPRRMTDHSI KECQKSLDFV LGWFAKPVFI DGDYPESMKN NLSSILPDFT ESEKKFIKGT ADFFALCFGP TLSFQLLDPH MKFRQLESPN LRQLLSWIDL EFNHPQIFIV ENGWFVSGTT KRDDAKYMYY LKKFIMETLK AIKLDGVDVI GYTAWSLMDG FEWHRGYSIR RGLFYVDFLS QDKMLLPKSS ALFYQKLIEK NGFPPLPENQ PLEGTFPCDF AWGVVDNYIQ VSQLTKPISS LTKPYHHHHH HH.
Purity : Greater than 90% as determined by SDS-PAGE.
Applications : ELISA, Immunoassays, Western blotting.
Stability : Store lyophilized Klotho Human recombinant at -20°C. Aliquot Klotho after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Reconstitution : It is recommended to add to Klothodeionized water to prepare a working stock solution of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter Klothoby an appropriate sterile filter before using it in the cell culture.
Gene Name : KL klotho [ Homo sapiens (human) ]
Official Symbol : KL
Synonyms : KL; klotho; EC 3.2.1.31; Klotho peptide; OTTHUMP00000018796; NP_004786.2
Gene ID : 9365
mRNA Refseq : NM_004795
Protein Refseq : NP_004786
MIM : 604824
UniProt ID : Q9UEF7
Chromosome Location : 13q12
Pathway : Adaptive Immune System; Constitutive PI3K/AKT Signaling in Cancer; Downstream signal transduction
Function : beta-glucosidase activity; beta-glucuronidase activity; fibroblast growth factor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does KL protein affect cognitive function? 04/08/2022

KL protein may have a neuroprotective role and is being studied for its potential in preserving cognitive function and preventing neurodegenerative diseases.

Are there any KL protein-based therapies available for clinical use? 04/07/2022

Currently, there are no FDA-approved KL protein-based therapies, but research in this area is ongoing.

Can KL protein supplementation slow down the aging process? 10/25/2021

While research suggests a connection between KL protein and aging, it is not yet clear if KL protein supplementation can effectively slow down the aging process in humans.

How is KL protein measured in clinical settings? 07/19/2018

KL protein levels can be measured in blood and urine samples using various laboratory techniques.

Are there any clinical trials exploring KL protein-based therapies? 04/28/2016

Yes, several clinical trials are investigating the potential therapeutic benefits of KL protein supplementation in kidney disease and other disorders.

Customer Reviews (3)

Write a review
Reviews
01/31/2021

    The KL protein's reliability and ease of use have made it an essential component of my structural investigations.

    01/22/2019

      Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.

      07/22/2016

        Furthermore, the KL protein has demonstrated great utility in protein electron microscopy structure analysis.

        Ask a Question for All KL Products

        Required fields are marked with *

        My Review for All KL Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends