"DKK1" Related Products

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Recombinant Human Dickkopf Homolog 1 (Xenopus laevis), His-tagged

Cat. No.: DKK1-347H
Product Overview: Recombinant human Dkk-1 protein, fused to His-tag at C-terminus, was expressed in Hi-5 cell using baculovirus expression system and purified by using conventional chromatography (253 aa, 27.8 kDa).
Description: Dickkopf-related protein 1, also known as Dkk-1, is a member of the Dkk protein family including Dkk-1, 2, 3 and -4. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated level of Dkk-1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
Source: Hi-5 cell.
Formulation: Liquid. In PBS (pH 7.4) containing 10% glycerol.
Molecular Weight: 27.8 kDa (253 aa).
Purity: > 85% by SDS – PAGE.
Concentration: 0.25 mg/ml (determined by Bradford assay).
Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method).
Sequence: ADPTLNSVLN SNAIKNLPPP LGGAAGHPGS AVSAAPGILY PGGNKYQTID NYQPYPCAED EECGTDEYCA SPTRGGDAGV QICLACRKRR KRCMRHAMCC PGNYCKNGIC VSSDQNHFRG EIEETITESF GNDHSTLDGY SRRTTLSSKM YHTKGQEGSV CLRSSDCASG LCCARHFWSK ICKPVLKEGQ VCTKHRRKGS HGLEIFQRCY CGEGLSCRIQ KDHHQASNSS RLHTCQRHSG RLVPRGSHHH HHH
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: DKK1
Synonyms: DKK1; dickkopf homolog 1 (Xenopus laevis); SK; DKK-1; Dickkopf-1; Dkk-1; hDkk-1; OTTHUMP00000019617; dickkopf homolog 1; dickkopf (Xenopus laevis) homolog 1; dickkopf-1 like; dickkopf related protein-1; DKK1 dickkopf homolog 1 (Xenopus laevis).
Gene ID: 22943
mRNA Refseq: NM_012242.2
Protein Refseq: NP_036374.1
MIM: 605189
UniProt ID: O94907
Chromosome Location: 10q11.2
Pathway: Wnt signaling pathway.
Function: growth factor activity; low-density lipoprotein receptor binding; protein binding; signal transducer activity.

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