Active Recombinant Human TNFRSF10B protein, Fc-tagged, FITC-labeled
Cat.No. : | TNFRSF10B-56H |
Product Overview : | Recombinant Human TNFRSF10B(aa 52-212) fused with the Fc portion of human IgG1 was expressed in HEK293, FITC conjugate. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Form : | Liquid. In PBS containing 0.02% sodium azide. |
Bio-activity : | Inhibits human soluble TRAIL-mediated apoptosis. |
Molecular Mass : | ~46kDa (SDS-PAGE). |
Endotoxin : | <0.1EU/µg purified protein (LAL test; Bio Whittaker). |
Purity : | ≥95% (SDS-PAGE) |
Applications : | Flow Cytometry: detection of TRAIL cell surface expression. |
Stability : | Stable for at least 6 months after receipt when stored at -20 centigrade. |
Storage : | Long Term Storage: -20 centigrade. Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20 centigrade. |
Concentration : | 1mg/ml |
Gene Name : | TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [ Homo sapiens ] |
Official Symbol : | TNFRSF10B |
Synonyms : | TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer); TRICK2; ZTNFR9; TRAILR2; TRICK2B; TRAIL-R2; KILLER/DR5; |
Gene ID : | 8795 |
mRNA Refseq : | NM_003842 |
Protein Refseq : | NP_003833 |
MIM : | 603612 |
UniProt ID : | O14763 |
Chromosome Location : | 8p22-p21 |
Pathway : | Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Caspase-8 is formed from procaspase-8, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; |
Function : | TRAIL binding; protein binding; receptor activity; |
Products Types
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◆ Lysates | ||
TNFRSF10B-2829HCL | Recombinant Human TNFRSF10B cell lysate | +Inquiry |
TNFRSF10B-2397MCL | Recombinant Mouse TNFRSF10B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionActivation of TNFRSF10B triggers apoptotic pathways, leading to programmed cell death in cancer cells.
TNFRSF10B has been implicated in certain autoimmune diseases and neurodegenerative disorders, highlighting its diverse roles in various physiological processes.
TNFRSF10B expression levels may serve as a potential diagnostic marker for certain cancers, aiding in cancer detection and prognosis.
TNFRSF10B expression is often altered in various cancers, including breast cancer, colorectal cancer, and lung cancer.
Side effects may occur, and ongoing research aims to minimize these effects while maximizing the therapeutic benefits of targeting TNFRSF10B.
Customer Reviews (3)
Write a reviewThe combination of high-quality TNFRSF10B protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.
The manufacturer's extensive experience and expertise in the field of TNFRSF10B protein research make them a trusted partner.
The manufacturer's commitment to providing excellent technical support is highly valuable.
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