Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human TNFRSF10B protein, Fc-tagged, FITC-labeled

Cat.No. : TNFRSF10B-56H
Product Overview : Recombinant Human TNFRSF10B(aa 52-212) fused with the Fc portion of human IgG1 was expressed in HEK293, FITC conjugate.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
Source : HEK293
Species : Human
Tag : Fc
Form : Liquid. In PBS containing 0.02% sodium azide.
Bio-activity : Inhibits human soluble TRAIL-mediated apoptosis.
Molecular Mass : ~46kDa (SDS-PAGE).
Endotoxin : <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Purity : ≥95% (SDS-PAGE)
Applications : Flow Cytometry: detection of TRAIL cell surface expression.
Stability : Stable for at least 6 months after receipt when stored at -20 centigrade.
Storage : Long Term Storage: -20 centigrade. Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20 centigrade.
Concentration : 1mg/ml
Gene Name : TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [ Homo sapiens ]
Official Symbol : TNFRSF10B
Synonyms : TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer); TRICK2; ZTNFR9; TRAILR2; TRICK2B; TRAIL-R2; KILLER/DR5;
Gene ID : 8795
mRNA Refseq : NM_003842
Protein Refseq : NP_003833
MIM : 603612
UniProt ID : O14763
Chromosome Location : 8p22-p21
Pathway : Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Caspase-8 is formed from procaspase-8, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem;
Function : TRAIL binding; protein binding; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does TNFRSF10B activation induce apoptosis in cancer cells? 03/09/2023

Activation of TNFRSF10B triggers apoptotic pathways, leading to programmed cell death in cancer cells.

Is TNFRSF10B involved in other diseases besides cancer? 04/19/2021

TNFRSF10B has been implicated in certain autoimmune diseases and neurodegenerative disorders, highlighting its diverse roles in various physiological processes.

Can TNFRSF10B be used as a diagnostic marker for cancer? 03/08/2019

TNFRSF10B expression levels may serve as a potential diagnostic marker for certain cancers, aiding in cancer detection and prognosis.

In what types of cancer is TNFRSF10B expression altered? 03/19/2017

TNFRSF10B expression is often altered in various cancers, including breast cancer, colorectal cancer, and lung cancer.

Are there any side effects associated with targeting TNFRSF10B in cancer treatment? 06/06/2016

Side effects may occur, and ongoing research aims to minimize these effects while maximizing the therapeutic benefits of targeting TNFRSF10B.

Customer Reviews (3)

Write a review
Reviews
08/11/2020

    The combination of high-quality TNFRSF10B protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

    10/07/2018

      The manufacturer's extensive experience and expertise in the field of TNFRSF10B protein research make them a trusted partner.

      03/04/2017

        The manufacturer's commitment to providing excellent technical support is highly valuable.

        Ask a Question for All TNFRSF10B Products

        Required fields are marked with *

        My Review for All TNFRSF10B Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends