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Recombinant Zebrafish AKIRIN1

Cat.No. : AKIRIN1-6376Z
Product Overview : Recombinant Zebrafish AKIRIN1 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Zebrafish
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : akirin1 akirin 1 [ Danio rerio (zebrafish) ]
Official Symbol : AKIRIN1
Gene ID : 406432
mRNA Refseq : NM_001113800
Protein Refseq : NP_001107272
UniProt ID : B0BLV7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (15)

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Can AKIRIN1 be used as a biomarker or therapeutic target? 11/25/2022

While there is ongoing research on the potential use of AKIRIN1 as a biomarker or therapeutic target, its clinical utility is still being investigated. AKIRIN1's involvement in immune responses and inflammatory processes suggests that it may have potential as a biomarker for certain diseases or as a target for therapeutic interventions. However, further studies are needed to validate its clinical relevance and explore its potential applications.

Does AKIRIN1 have any role in embryonic development? 03/10/2022

Yes, AKIRIN1 has been shown to play a role in embryonic development. Studies in animal models have demonstrated that AKIRIN1 is necessary for proper organ development and embryonic patterning. Knockout of AKIRIN1 in mice leads to embryonic lethality with severe defects in organogenesis, such as heart abnormalities and disrupted neural tube development. AKIRIN1 has also been implicated in the development of skeletal muscle, as it regulates myoblast fusion and muscle fiber formation.

Is AKIRIN1 expressed in all tissues or specific tissues? 01/21/2022

AKIRIN1 is expressed in a wide range of tissues and cell types. It has been detected in various organs, including the liver, brain, heart, skeletal muscle, and immune cells. Its expression can vary among different tissues and may be influenced by specific cellular states or stimuli.

Is AKIRIN1 involved in inflammatory processes? 11/14/2021

Yes, AKIRIN1 is involved in inflammatory processes. It can regulate the production of inflammatory cytokines and chemokines by immune cells. AKIRIN1 has been shown to modulate the activity of NF-κB, a key transcription factor involved in the inflammatory response, leading to the regulation of pro-inflammatory gene expression. It can also participate in the formation of inflammatory signaling complexes, such as the IKK complex, to regulate immune cell activation and inflammation.

Can AKIRIN1 modulate muscle regeneration? 11/09/2020

Yes, AKIRIN1 has been shown to play a role in muscle regeneration. It is involved in the fusion of myoblasts to form multinucleated muscle fibers, which is a critical process in muscle regeneration and repair. AKIRIN1 promotes myoblast fusion by regulating the expression of genes involved in cell adhesion and membrane fusion. Additionally, AKIRIN1 has been found to enhance skeletal muscle regeneration by promoting myogenic differentiation and muscle stem cell activation.

Does AKIRIN1 have any known protein partners or interactors? 06/04/2020

Yes, AKIRIN1 has been found to interact with various proteins. One of its main interacting partners is the transcription factor NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells). AKIRIN1 forms a complex with NF-κB and acts as a co-regulator to enhance or suppress NF-κB-dependent gene expression. Additionally, AKIRIN1 can interact with other transcription factors and chromatin remodeling complexes to modulate gene expression.

What techniques are used to study AKIRIN1 protein? 10/26/2019

Various techniques are employed to study the AKIRIN1 protein. These include molecular biology techniques like PCR (polymerase chain reaction) and gene cloning for studying its expression and genetic variants. Immunoblotting and immunofluorescence can be used to detect and visualize AKIRIN1 protein levels and subcellular localization. Co-immunoprecipitation and affinity purification techniques can be used to identify protein partners or interactors of AKIRIN1.

How is AKIRIN1 regulated? 12/08/2018

The regulation of AKIRIN1 expression and activity is complex and involves multiple mechanisms. AKIRIN1 itself can undergo post-translational modifications, such as phosphorylation and acetylation, which can modulate its function and stability. Additionally, AKIRIN1 expression can be regulated at the transcriptional level by various transcription factors and signaling pathways. For example, nuclear factor-kappa B (NF-κB) signaling has been shown to induce the expression of AKIRIN1 in response to inflammatory stimuli. Furthermore, AKIRIN1 can form protein complexes with other regulatory factors and proteins, which can influence its activity and localization.

Can AKIRIN1 modulate immune cell differentiation? 08/01/2018

Yes, AKIRIN1 has been shown to play a role in immune cell differentiation. It can regulate the development and maturation of immune cells such as T cells and B cells. In T cells, AKIRIN1 has been found to regulate the expression of key transcription factors involved in T cell differentiation, such as T-bet and GATA3. It can also modulate the cytokine production and functional properties of T cells. In B cells, AKIRIN1 has been shown to be essential for the development and function of marginal zone B cells, a subset of B cells involved in antibody production against blood-borne pathogens.

Are there any known genetic variants or mutations in the AKIRIN1 gene? 02/02/2018

Yes, there are known genetic variants and mutations in the AKIRIN1 gene. For example, some studies have identified single nucleotide polymorphisms (SNPs) in the AKIRIN1 gene that are associated with certain autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. These genetic variants may affect the expression or function of AKIRIN1 and contribute to the development or progression of these diseases.

Is AKIRIN1 linked to any diseases or conditions? 09/28/2017

AKIRIN1 has been implicated in various diseases and conditions. Its involvement in the NF-κB signaling pathway suggests its potential role in inflammation-related disorders, autoimmune diseases, and cancer progression. Additionally, AKIRIN1 has been associated with skeletal muscle development and regeneration and may be relevant in muscle disorders and regeneration therapies. However, further research is needed to fully understand the precise contribution of AKIRIN1 to these diseases and conditions.

What are the known functions of AKIRIN1? 12/30/2016

AKIRIN1 is known to play various roles in different biological processes. It has been primarily studied in the context of immune responses and inflammatory processes. AKIRIN1 acts as a transcriptional regulator and modulates the expression of genes involved in immune cell development, differentiation, and function. It also regulates the production of inflammatory cytokines and chemokines. Additionally, AKIRIN1 has been implicated in skeletal muscle development and regeneration, as well as embryonic development and organ formation.

Is AKIRIN1 conserved across different species? 11/28/2016

Yes, AKIRIN1 is highly conserved across different species. Its homologs have been identified in various organisms, including mammals, birds, fish, insects, and nematodes. The conservation of AKIRIN1 across species suggests its important biological functions and its evolutionary significance.

What signaling pathways is AKIRIN1 involved in? 05/04/2016

AKIRIN1 is primarily associated with the NF-κB signaling pathway, which is a key regulator of inflammation and immune responses. AKIRIN1 interacts with the NF-κB transcription factor and can either enhance or suppress NF-κB-dependent gene expression, thereby influencing immune responses and inflammatory processes. In addition to NF-κB signaling, AKIRIN1 may also be involved in other signaling pathways, although further studies are needed to elucidate these interactions.

Are there any diseases or disorders associated with AKIRIN1? 01/31/2016

Although further studies are needed to fully understand the implications of AKIRIN1 in disease development, there is increasing evidence linking AKIRIN1 to certain diseases and disorders. For example, dysregulation of AKIRIN1 expression or function has been associated with autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. AKIRIN1 has also been implicated in cancer development and progression, particularly in breast cancer and hepatocellular carcinoma. Additionally, AKIRIN1 may play a role in muscular dystrophy and skeletal muscle disorders, as it is involved in muscle development and regeneration processes.

Customer Reviews (4)

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Reviews
03/18/2022

    The AKIRIN1 protein excels in terms of quality and perfectly aligns with my experimental requirements.

    05/16/2019

      In addition to its outstanding quality, the manufacturer of the AKIRIN1 protein provides excellent technical support.

      12/22/2015

        With its high level of purity and reliability, this protein is poised to fulfill all my research needs.

        05/05/2015

          The AKIRIN1 protein's exceptional attributes make it an ideal choice, ensuring accurate and consistent results throughout my experiments.

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