Recombinant Human Slow Cardiac Myosin Regulatory light chain 2, His-tagged
Cat.No. : | MYL2-388H |
Product Overview : | Recombinant human MYL2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques, 20.9 kDa (186aa) |
- Specification
- Gene Information
- Related Products
Cat. No. : | MYL2-388H |
Description : | Myosin, light chain 2 (MYL2) encodes the regulatory light chain associated with cardiac myosin beta heavy chain. It is an important protein involved in the regulation of myosin ATPase activity in smooth muscle and Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MAPKKAKKRA GGANSNVFSM FEQTQIQEFK EAFTIMDQNR DGFIDKNDLR DTFAALGRVN VKNEEIDEMI KEAPGPINFT VFLTMFGEKL KGADPEETIL NAFKVFDPEG KGVLKADYVR EMLTTQAERF SKEEVDQMFA AFPPDVTGNL DYKNLVHIIT HGEEKD |
Formulation : | Liquid in 20mM Tris-HCl (pH 8.0) containing 20% glycerol 5mM CaCl2 |
Purity : | > 95% by SDS PAGE |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | MYL2 myosin, light chain 2, regulatory, cardiac, slow [ Homo sapiens ] |
Synonyms : | MYL2; myosin, light chain 2, regulatory, cardiac, slow; MLC2; CMH10; DKFZp779C0562; MYL2; slow cardiac myosin regulatory light chain 2; RLC of myosin; myosin light chain 2; regulatory light chain of myosin; cardiac ventricular myosin light chain 2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2v; myosin regulatory light chain 2, ventricular/cardiac muscle isoform |
Gene ID : | 4633 |
mRNA Refseq : | NM_000432 |
Protein Refseq : | NP_000423 |
MIM : | 160781 |
UniProt ID : | P10916 |
Chromosome Location : | 12q24.11 |
Function : | actin monomer binding; calcium ion binding; motor activity ;myosin heavy chain binding; protein binding; structural constituent of muscle |
Products Types
◆ Recombinant Protein | ||
MYL2-1467H | Recombinant Human MYL2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MYL2-3513R | Recombinant Rat MYL2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MYL2-10314M | Recombinant Mouse Myl2 Protein, Myc/DDK-tagged | +Inquiry |
Myl2-4250M | Recombinant Mouse Myl2 Protein, Myc/DDK-tagged | +Inquiry |
MYL2-5808H | Recombinant Human MYL2 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
MYL2-4028HCL | Recombinant Human MYL2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionStudies suggest that MYL2 expression levels may vary with age and gender, which could have implications for understanding cardiac health across different demographics.
Elevated MYL2 levels may be indicative of a poorer prognosis in certain cardiac conditions, providing valuable information for treatment planning.
Understanding the genetic variations in MYL2 allows for personalized treatment strategies tailored to an individual's specific cardiac profile.
Dysregulation of MYL2 is implicated in hypertrophic cardiomyopathy, contributing to our understanding of the molecular pathways leading to cardiac hypertrophy.
Analyzing MYL2 variants and expression levels can help identify individuals at a higher risk of developing cardiac disorders, allowing for proactive management.
Customer Reviews (3)
Write a reviewThe MYL2 Protein comes highly recommended for its exceptional performance, particularly in ELISA assays.
This protein has proven to be of great utility in protein electron microscopy structure analysis.
Researchers utilizing the MYL2 Protein can rely on its robust and reproducible performance in a variety of experimental settings.
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