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Recombinant Zebrafish ALCAMA

Cat.No. : ALCAMA-8633Z
Product Overview : Recombinant Zebrafish ALCAMA full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Zebrafish
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : alcama activated leukocyte cell adhesion molecule a [ Danio rerio (zebrafish) ]
Official Symbol : ALCAMA
Gene ID : 30194
mRNA Refseq : NM_131000
Protein Refseq : NP_571075
UniProt ID : Q90460

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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Is ALCAMa protein involved in any other physiological processes? 01/13/2023

In addition to its roles in cell adhesion, migration, and signaling, ALCAMa protein has been implicated in various other physiological processes. It plays a role in the development and maintenance of the nervous system, including axon guidance, synapse formation, and neuronal plasticity. ALCAMa is also involved in tissue morphogenesis, such as organogenesis and wound healing, where it contributes to cell-cell interactions and tissue remodeling.

How is ALCAMa expression regulated during development? 10/16/2022

The regulation of ALCAMa expression during development is complex and involves various signaling pathways and transcription factors. For example, during embryogenesis, ALCAMa expression is controlled by the Wnt/β-catenin pathway, Notch signaling, and other developmental regulators. Additionally, tissue-specific transcription factors can modulate ALCAMa expression in different cell types. The precise mechanisms underlying ALCAMa regulation during development are still being elucidated and are the subject of ongoing research.

Does ALCAMa play a role in stem cell biology? 08/08/2022

ALCAMa has been implicated in stem cell biology. It is involved in regulating the self-renewal and differentiation of various types of stem cells, including embryonic stem cells and neural stem cells. ALCAMa interactions with other cell adhesion molecules can influence stem cell fate decisions and contribute to tissue regeneration and repair.

Can ALCAMa be used as a biomarker for cancer diagnosis or prognosis? 06/10/2021

ALCAMa expression has been studied as a potential biomarker for cancer diagnosis and prognosis. Elevated levels of ALCAMa have been found in the blood, serum, and tumor tissues of patients with certain cancer types. Its overexpression has been associated with increased tumor aggressiveness and poorer outcomes. However, further research is needed to establish its specific value as a diagnostic or prognostic biomarker, as its utility may vary depending on the cancer type and individual patient characteristics.

Are there any inhibitors or antibodies targeting ALCAMa being developed for therapeutic use? 05/20/2021

The development of specific inhibitors or antibodies targeting ALCAMa for therapeutic use is an area of ongoing research. While there are no approved drugs targeting ALCAMa at present, preclinical studies have shown promising results. For example, some studies have investigated the use of monoclonal antibodies or antibody-drug conjugates targeting ALCAMa in cancer therapy. These approaches aim to disrupt ALCAMa-mediated signaling or deliver cytotoxic agents directly to ALCAMa-expressing tumor cells. However, the development and testing of these potential therapies are still in the early stages.

Are there any known drugs or compounds that can modulate ALCAMa activity? 04/01/2021

Currently, there are no specific drugs or compounds that are known to directly modulate ALCAMa activity. However, certain compounds and inhibitors targeting upstream signaling pathways or enzymes involved in cell adhesion and migration, such as integrins or metalloproteases, may indirectly affect ALCAMa function. These compounds are still under investigation and may have potential therapeutic implications for diseases involving ALCAMa dysregulation.

Where is ALCAMa protein expressed? 01/11/2021

ALCAMa protein is expressed in various tissues and cell types. It is found in high levels in leukocytes, activated T lymphocytes, neural tissues, endothelial cells, and certain epithelial tissues. ALCAMa expression can also be upregulated in various cancers.

Does ALCAMa have any known roles in neurodevelopmental disorders? 08/11/2020

ALCAMa has been implicated in neurodevelopmental disorders, such as autism spectrum disorder (ASD) and schizophrenia. It is involved in neuronal development, synaptic plasticity, and connectivity, processes that are altered in these disorders. However, more research is needed to fully understand the specific roles of ALCAMa in neurodevelopmental disorders and its potential as a therapeutic target.

Can ALCAMa be used as a biomarker in cancer diagnosis? 06/15/2020

ALCAMa has been investigated as a potential biomarker in cancer diagnosis. Increased expression of ALCAMa has been detected in cancer tissues compared to normal tissues, and it has shown promise as a diagnostic marker in certain cancer types. However, further research is needed to validate its diagnostic utility and determine its sensitivity and specificity as a cancer biomarker.

Is there any known association between ALCAMa and autoimmune diseases? 09/03/2019

There is limited evidence linking ALCAMa to autoimmune diseases. Some studies have suggested that ALCAMa expression may be dysregulated in autoimmune disorders like rheumatoid arthritis and multiple sclerosis. However, more research is required to fully understand the role of ALCAMa in autoimmune diseases and whether it directly contributes to disease pathogenesis or if its altered expression is secondary to other immune system dysfunctions.

Are there any diseases or disorders associated with mutations in the ALCAM gene? 08/29/2019

Mutations in the ALCAM gene have been associated with certain diseases and disorders. For example, mutations in the ALCAM gene have been linked to recessive forms of the hereditary lymphedema (Lymphedema type IA) and hypoparathyroidism-retardation-dysmorphism syndrome (HRDS). These mutations result in the production of non-functional or partially functional ALCAMa protein, leading to abnormal lymphatic development and developmental abnormalities.

ow is ALCAMa involved in neuron-glia interactions? 04/01/2019

ALCAMa plays a significant role in neuron-glia interactions, which are essential for proper neural development and function. It regulates cell adhesion and signaling between neurons and glial cells, including astrocytes, oligodendrocytes, and microglia.

Are there any ongoing clinical trials involving ALCAMa protein? 02/01/2019

As of now, there are no registered clinical trials specifically targeting ALCAMa protein. However, there may be trials investigating therapies or biomarkers related to cancer, neurodevelopmental disorders, or other disease conditions where ALCAMa is implicated. Keeping track of ongoing clinical trials through relevant databases can provide up-to-date information on the status of ALCAMa-related research.

Is ALCAMa protein secreted or membrane-bound? 03/03/2018

ALCAMa protein is primarily membrane-bound, with a transmembrane domain that anchors it to the cell membrane. However, in some cases, ALCAMa can undergo proteolytic cleavage, leading to the release of a soluble form of ALCAMa into the extracellular space. The soluble form of ALCAMa can have distinct functional properties and may act as a modulator of cell adhesion and signaling processes.

Is ALCAMa associated with cancer? 06/16/2017

Yes, ALCAMa has been implicated in cancer. Increased expression of ALCAMa has been observed in various cancer types, including breast, colorectal, lung, ovarian, and pancreatic cancers. ALCAMa overexpression has been associated with tumor aggressiveness, metastasis, and poor prognosis in some cases.

Can ALCAMa be used as a target for immunotherapy? 05/08/2017

ALCAMa has shown potential as a target for immunotherapy in certain cancer types. Antibodies targeting ALCAMa have been investigated as a potential treatment strategy. These antibodies can bind to ALCAMa on tumor cells, leading to antibody-dependent cell-mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC), effectively killing the tumor cells. However, more research is needed to optimize the therapeutic efficacy and minimize potential side effects of ALCAMa-targeted immunotherapy.

What are the functions of other variants of the ALCAM gene? 07/16/2016

The ALCAM gene encodes multiple isoforms or variants of the ALCAM protein. Apart from ALCAMa, which is the most extensively studied isoform, other variants include ALCAMb and ALCAMc. These isoforms can have similar or distinct functions compared to ALCAMa. While ALCAMa is primarily expressed in epithelial cell types, ALCAMb and ALCAMc are more commonly found in neural tissues. They may contribute to neural development, synaptic organization, or other processes specific to the nervous system.

Can ALCAMa be targeted for therapeutic purposes in autoimmune diseases? 03/16/2016

The potential of targeting ALCAMa for therapeutic purposes in autoimmune diseases is still under investigation. ALCAMa is involved in immune cell adhesion and migration, and modulating its function may help regulate immune responses in autoimmune diseases. However, further research is needed to assess the efficacy and safety of targeting ALCAMa in the context of specific autoimmune conditions.

How is ALCAMa regulated in cells? 02/24/2016

The expression and function of ALCAMa protein can be regulated by various mechanisms. Transcriptional regulation controls the levels of ALCAMa mRNA, thereby influencing protein expression. Additionally, post-translational modifications, such as glycosylation and phosphorylation, can impact ALCAMa protein stability and activity. Furthermore, interactions with other proteins, such as cytoskeleton-associated molecules and signaling receptors, can modulate ALCAMa function and downstream signaling pathways.

Are there any targeted therapies that can inhibit ALCAMa? 01/27/2016

Currently, there are no specific targeted therapies designed specifically to inhibit ALCAMa protein. However, research is ongoing to develop therapeutic strategies that can modulate ALCAMa function or disrupt its interactions. These strategies may involve the use of antibodies, small molecules, or other targeted approaches.

Customer Reviews (4)

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Reviews
12/22/2020

    The ALCAMA protein has demonstrated remarkable stability, allowing for extended storage without compromising its quality.

    11/14/2020

      The ALCAMA (Activated Leukocyte Cell Adhesion Molecule A) protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.

      05/30/2019

        Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.

        07/23/2017

          One aspect that sets the ALCAMA protein apart is the excellent technical support provided by the manufacturer.

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