"PSMD10" Related Products

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Recombinant Human Proteasome (prosome, macropain) 26S Subunit, Non-ATPase, 10

Cat. No.: PSMD10-358H
Product Overview: Recombinant human PSMD10 was expressed in E.coli and purified by conventional chromatography techniques, 24.4kDa (226aa).
Description: PSMD10 is an oncoprotein commonly overexpressed in most hepatocellular carcinomas. Gankyrin interacts with S6 ATPase of the 19S regulatory particle of the 26S proteasome. It is known to play a role in the regulation of the phosphorylation of the retinoblastoma protein by CDK4, and to enhance the ubiquitinylation of p53 by MDM2. Gankyrin consists of 7 ankyrin repeats and is structurally similar to I kappa Bs.
Source: Escherichia Coli.
Form: Liquid. In Phosphate buffered saline (pH7.4), 10% glycerol
Purity: > 95% by SDS - PAGE.
Concentration: 1 mg/ml (determined by Bradford assay)
Sequences of amino acids: MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 [ Homo sapiens ]
Synonyms: Gankyrin; OTTHUMP00000023827; OTTHUMP00000023828; dJ889N15.2; gankyrin; p28; 26S proteasome regulatory subunit p28; ankyrin repeat protein; hepatocellular carcinoma-associated protein p28-II; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; proteasome 26S non-ATPase subunit 10; PSMD10; 26S proteasome non-ATPase regulatory subunit 10.
Gene ID: 5716
mRNA Refseq: NM_002814
Protein Refseq: NP_002805
MIM: 603480
UniProt ID: O75832
Chromosome Location: Xq22.3
Function: protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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