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Recombinant Zebrafish ARHGAP11A

Cat.No. : ARHGAP11A-12503Z
Product Overview : Recombinant Zebrafish ARHGAP11A full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Zebrafish
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : arhgap11a Rho GTPase activating protein 11A [ Danio rerio (zebrafish) ]
Official Symbol : ARHGAP11A
Gene ID : 406608
mRNA Refseq : NM_213316
Protein Refseq : NP_998481
UniProt ID : X1WDM4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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Is ARHGAP11A targeted by any microRNAs? 12/01/2021

MicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate gene expression. Although specific miRNAs targeting ARHGAP11A have not been extensively documented, some miRNAs, such as miR-17-5p and miR-429, have been reported to interact with ARHGAP11A in certain contexts. These miRNAs may modulate ARHGAP11A expression levels, but further studies are needed to fully understand the regulatory interactions between miRNAs and ARHGAP11A.

Is ARHGAP11A protein specific to any particular cell type? 10/14/2021

ARHGAP11A is expressed in various cell types, including epithelial cells, fibroblasts, neurons, and immune cells. Its expression pattern suggests that it has diverse functions in different cell contexts.

Is ARHGAP11A differentially expressed in different tissues? 06/18/2021

Yes, ARHGAP11A exhibits differential expression patterns in different tissues. It is expressed in various tissues and cell types, including the brain, heart, liver, and immune cells. The levels of ARHGAP11A expression can vary depending on the tissue and the developmental stage. For example, ARHGAP11A is highly expressed in the brain, particularly in regions involved in learning and memory processes. However, tissue-specific expression patterns and their functional significance require further investigation.

Does ARHGAP11A have any known role in immune responses? 09/06/2020

Limited research has suggested a potential role for ARHGAP11A in immune responses. It has been implicated in the regulation of immune cell migration and adhesion, as well as inflammatory signaling pathways. However, further studies are needed to fully understand its involvement in immune responses.

Are there any known genetic or epigenetic factors that influence ARHGAP11A expression? 07/28/2020

While specific genetic or epigenetic factors that directly influence ARHGAP11A expression are not well-established, it is possible that mutations or epigenetic modifications in the regulatory regions of the ARHGAP11A gene could alter its expression levels. Further research is needed to fully understand the regulatory mechanisms governing ARHGAP11A expression.

Can ARHGAP11A be used as a biomarker for any diseases? 06/09/2020

There is limited information regarding the use of ARHGAP11A as a biomarker for specific diseases. However, altered expression or genetic variations in ARHGAP11A have been observed in certain diseases, such as cancer and neurodevelopmental disorders. These findings suggest that ARHGAP11A may have potential as a biomarker for disease prognosis or diagnostic purposes. Nonetheless, more research is needed to establish its clinical utility as a biomarker.

Are there any diseases associated with mutations or dysregulation of ARHGAP11A? 11/05/2019

While specific diseases linked to ARHGAP11A mutations are currently not well-established, dysregulation of ARHGAP11A has been observed in certain cancers, suggesting a potential role in cancer progression. Further research is needed to explore its involvement in other diseases or disorders.

Does ARHGAP11A play a role in neuronal development? 09/08/2019

Yes, ARHGAP11A has been implicated in neuronal development and neuronal migration. It is involved in regulating the cytoskeletal dynamics required for proper neuron migration during brain development.

How does ARHGAP11A affect cell migration? 06/21/2019

ARHGAP11A promotes cell migration by inhibiting the activity of RhoA, a Rho GTPase that suppresses cell motility. By inactivating RhoA, ARHGAP11A allows for cytoskeletal remodeling and cell movement.

Is ARHGAP11A involved in neuronal development or function? 05/02/2019

Yes, ARHGAP11A is involved in neuronal development and function. It has been shown to play a role in axon guidance and neuronal migration during brain development. Furthermore, ARHGAP11A has been linked to synaptic plasticity and cognitive function, making it a relevant protein in the context of neurodevelopmental disorders.

Are there any known interactions of ARHGAP11A with other proteins? 04/03/2019

Yes, ARHGAP11A has been reported to interact with several proteins involved in cellular signaling and cytoskeletal dynamics. For example, it can associate with Rho GTPases, such as RhoA and Rac1, to regulate their activity. ARHGAP11A has also been shown to interact with actin-binding proteins, such as cortactin, which may help mediate its effects on cytoskeletal remodeling.

Are there any known functional domains in the ARHGAP11A protein? 03/02/2019

Yes, ARHGAP11A contains several functional domains, including a RhoGAP domain. The RhoGAP domain is responsible for its ability to inactivate Rho GTPases by promoting the hydrolysis of GTP to GDP, thereby regulating their signaling.

Are there any known genetic polymorphisms or mutations in the ARHGAP11A gene? 09/08/2018

There have been reports of genetic variations, including single nucleotide polymorphisms (SNPs), in the ARHGAP11A gene. Some studies have associated certain SNPs in ARHGAP11A with increased risk for neurodevelopmental disorders, while others have identified variations in ARHGAP11A as potential biomarkers for cancer prognosis. However, more research is required to determine the functional significance of these genetic variations.

Does ARHGAP11A have any isoforms or splice variants? 01/18/2018

Yes, ARHGAP11A has several isoforms and splice variants resulting from alternative splicing of its mRNA. These isoforms may have distinct functions or subcellular localizations.

Are there any drugs or compounds that target ARHGAP11A? 07/27/2017

As of now, there are no specific drugs or compounds that directly target ARHGAP11A. However, since ARHGAP11A regulates Rho GTPases, compounds that modulate Rho GTPase activity, such as Rho GTPase inhibitors or activators, may indirectly affect ARHGAP11A's function. Additionally, further research on ARHGAP11A biology may identify potential therapeutic targets or strategies for diseases associated with its dysfunction.

Are there any drugs or therapeutic approaches targeting ARHGAP11A? 05/09/2017

Currently, there are no specific drugs or therapeutic approaches targeting ARHGAP11A. However, understanding its role in cancer and other diseases could potentially lead to the development of targeted therapies in the future.

Is ARHGAP11A protein found in the nucleus or the cytoplasm? 03/05/2017

ARHGAP11A protein is primarily localized to the cytoplasm of cells, where it interacts with various cellular components and mediates its functions. However, it can also translocate to the nucleus in response to specific signaling events or interactions with other proteins.

Are there any diseases or disorders associated with ARHGAP11A dysfunction? 11/02/2016

While not extensively studied, ARHGAP11A dysfunction has been associated with certain diseases and disorders. For instance, mutations or dysregulation of ARHGAP11A have been implicated in developmental disorders, such as intellectual disability and autism spectrum disorder. Additionally, altered expression of ARHGAP11A has been observed in various cancers, suggesting a potential role in disease progression.

Does ARHGAP11A play a role in cancer progression? 04/07/2016

Yes, ARHGAP11A has been implicated in cancer progression. It can act either as a tumor suppressor or a tumor promoter, depending on the context and cancer type. For example, ARHGAP11A has been found to inhibit cell migration and invasion in breast cancer, while promoting cell proliferation and metastasis in liver cancer. Its role in cancer is still being actively studied.

Are there any known interacting proteins or partners of ARHGAP11A? 01/19/2016

Yes, several proteins have been identified as interacting partners of ARHGAP11A. These include other Rho GTPases, such as RhoA, Rac1, and Cdc42, as well as various cytoskeletal proteins and scaffold proteins involved in signaling pathways. Interactions with these proteins contribute to the regulation of ARHGAP11A's functions.

Customer Reviews (8)

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Reviews
08/01/2022

    The manufacturer of ARHGAP11A protein has consistently provided outstanding technical support that has surpassed my expectations.

    04/01/2022

      Their dedication to customer satisfaction has been instrumental in overcoming obstacles and achieving successful results in my experiments.

      02/27/2021

        This variety allows me to select the most appropriate option based on the specific requirements of my research.

        01/23/2020

          the manufacturer's commitment to quality control and rigorous testing guarantees the reliability and reproducibility of the ARHGAP11A protein, which is essential for obtaining accurate and consistent results.

          10/10/2018

            I am delighted to express my complete satisfaction with the quality of ARHGAP11A protein, as it precisely suits my experimental requirements.

            06/10/2018

              This protein demonstrates remarkable purity, stability, and specificity, ensuring utmost accuracy and reproducibility in my research endeavors.

              10/25/2016

                With its remarkable quality, reliability, and the manufacturer's excellent technical support, I am confident that it will be an invaluable asset in driving my scientific inquiries forward and facilitating groundbreaking discoveries in my field.

                07/27/2016

                  Their expertise in protein production and purification ensures the delivery of a high-quality product that consistently performs well in my experiments.

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