Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), A30P/A53T

Cat. No.: SNCA-290H
Product Overview: Recombinant Human α-Synuclein A30P/A53T protein produced in E.Coli encodes 1-140 amino acids and has a molecular mass of 14.5 kDa.
Description: A Parkinson's disease-related double mutant (A30P/A53T) of α-synuclein. The recombinant protein was purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques.
Source: E.coli.
Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl.
Molecular Weight: 14.5 kDa (140 aa)(Real molecular size on SDS-PAGE will be shift up).
Purity: > 95% by SDS PAGE.
Concentration: 1mg/ml (determined by BCA assay).
Sequence: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAP GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Storage: Store at -20 °C. Avoid freeze/thaw cycles.
Gene Name: SNCA
Synonyms: SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; MGC110988; alpha-synuclein, isoform NACP140; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; alpha-synuclein; OTTHUMP00000161559; OTTHUMP00000161561; non A-beta component of AD amyloid; synuclein, alpha (non A4 component of amyloid precursor); Synuclein, alpha (non-Abeta component of Alzheimer"s disease amyloid precursor protein: NACP).
Gene ID: 6622
mRNA Refseq: NM_000345.3
Protein Refseq: NP_000336.1
MIM: 163890
UniProt ID: P37840
Chromosome Location: 4q21
Pathway: Alzheimer"s disease; Neurodegenerative Disorders; Parkinson"s disease.
Function: Hsp70 protein binding; alpha-tubulin binding; dynein binding; histone binding; kinesin binding; tau protein binding; transferrin transmembrane transporter activity.

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