Active Recombinant Human Basic Fibroblast Growth Factor

• Cat.No.: FGF2-5H
• Product Overview: Human basic FGF is produced by genetically engineered yeast, and purified by heparin-Sepharose affinity chromatography.

Specification

• Description: Human Basic Fibroblast Growth Factor is a mitogen that stimulates cell growth for such cells as fibroblasts, endothelial cells, myoblasts, glial cells and smooth muscle cells. Basic FGF is composed of 146 amino acid residues (pro 1 to ser 146), and is 55% homologous with acidic FGF, including two conserved cysteine residues.
• Source: yeast
• Species: Human
• Form: Lyophilized powder
• Bio-activity: The mitogenic activity of human basic FGF is identical to natural bovine basic FGF, as measured by stimulation of 3H-thymidine incorporation into human foreskin fibroblast cells.
• Molecular Mass: 17.5 KDa
• Purity: Over 95% pure by N-terminal amino acid sequencing, amino acid composition, HPLC analysis, and SDS gel electrophoresis.
• Stability: Several months, lyophilized or in solution, at pH 6-7 and +4°C.
• Storage: Store at +4°C. Reconstitution is best in water or buffer near neutral pH, since it is unstable in acidic solutions. After reconstitution, storage in aliquots at -80°C is recommended.

Gene Information

• Gene Name: FGF2 fibroblast growth factor 2 (basic) [ Homo sapiens (human) ]
• Official Symbol: FGF2
• Synonyms: FGF2; fibroblast growth factor 2 (basic); BFGF; FGFB; HBGF-2; fibroblast growth factor 2; prostatropin; heparin-binding growth factor 2; basic fibroblast growth factor Bfgf; Basic fibroblast growth factor
• Gene ID: 2247
• mRNA Refseq: NM_002006
• Protein Refseq: NP_001997
• MIM: 134920
• UniProt ID: P09038
• Chromosome Location: 4q26
• Pathway: Activated point mutants of FGFR2; Adaptive Immune System; Angiopoietin receptor Tie2-mediated signaling
• Function: chemoattractant activity; cytokine activity; fibroblast growth factor receptor binding