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Recombinant Human TBXAS1, MYC/DDK-tagged

Cat.No. : TBXAS1-3149H
Product Overview : Recombinant Human TBXAS1, transcript variant TXS-I, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
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Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : HEK293 cells
Species : Human
Tag : MYC/DDK
Molecular Mass : 60.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : TBXAS1 thromboxane A synthase 1 (platelet) [ Homo sapiens (human) ]
Official Symbol : TBXAS1
Synonyms : TBXAS1; thromboxane A synthase 1 (platelet); thromboxane A synthase 1 (platelet, cytochrome P450, subfamily V); thromboxane-A synthase; CYP5; CYP5A1; cytochrome P450; family 5; subfamily A; polypeptide 1; THAS; TS; TXAS; TXS; TXA synthase; cytochrome P450 5A1; platelet, cytochrome P450, subfamily V; cytochrome P450, family 5, subfamily A, polypeptide 1; thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A); GHOSAL; BDPLT14; FLJ52771
Gene ID : 6916
mRNA Refseq : NM_001061
Protein Refseq : NP_001052
MIM : 274180
UniProt ID : P24557
Chromosome Location : 7q34-q35
Pathway : Arachidonic acid metabolism; Biological oxidations; Defective CYP19A1 causes Aromatase excess syndrome (AEXS); Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Function : heme binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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