Recombinant Human CTTN, MYC/DDK-tagged

• Cat.No.: CTTN-28H
• Product Overview: Recombinant Human CTTN, transcript variant 2, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Description: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
• Source: HEK293 cells
• Species: Human
• Tag: MYC/DDK
• Molecular Mass: 57.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: CTTN cortactin [ Homo sapiens (human) ]
• Official Symbol: CTTN
• Synonyms: CTTN; cortactin; EMS1, ems1 sequence (mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); src substrate cortactin
• Gene ID: 2017
• mRNA Refseq: NM_138565
• Protein Refseq: NP_612632
• MIM: 164765
• UniProt ID: Q14247
• Chromosome Location: 11q13
• Pathway: Bacterial invasion of epithelial cells; FGF signaling pathway; Pathogenic Escherichia coli infection
• Function: protein binding