Recombinant Human IL17RB, hIgG-His-tagged
Cat.No. : | IL17RB-41H |
Product Overview : | Recombinant human IL17RB, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
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Description : | IL17RB, also known as Interleukin-17 receptor B, is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. It has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. It was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. |
Source : | Insect cell |
Species : | Human |
Tag : | hIgG-His |
Form : | Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol. |
Molecular Mass : | 57.2kDa (514aa), Reducing conditions 50-70KDa (SDS-PAGE under reducing conditions.) |
AA Sequence : | REPTVQCGSE TGPSPEWMLQ HDLIPGDLRD LRVEPVTTSV ATGDYSILMN VSWVLRADAS IRLLKATKIC VTGKSNFQSY SCVRCNYTEA FQTQTRPSGG KWTFSYIGFP VELNTVYFIG AHNIPNANMN EDGPSMSVNF TSPGCLDHIM KYKKKCVKAG SLWDPNITAC KKNEETVEVN FTTTPLGNRY MALIQHSTII GFSQVFEPHQ KKQTRASVVI PVTGDSEGAT VQLTPYFPTC GSDCIRHKGT VVLCPQTGVP FPLDNNKSKP GGWLPVEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH |
Endotoxin : | < 1.0 eu per 1 microgram of protein (determined by lal |
Purity : | >85% by SDS - PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25mg/ml (determined by Bradford assay) |
Gene Name : | IL17RB interleukin 17 receptor B [ Homo sapiens ] |
Official Symbol : | IL17RB |
Synonyms : | IL17RB; interleukin 17 receptor B; IL17BR, interleukin 17B receptor; interleukin-17 receptor B; CRL4; EVI27; IL17RH1; IL-17RB; IL-17Rh1; IL-17B receptor; IL-17 receptor B; cytokine receptor CRL4; IL-17 receptor homolog 1; cytokine receptor-like 4; interleukin 17B receptor; interleukin-17B receptor; interleukin 17 receptor homolog 1; IL17BR; MGC5245; |
Gene ID : | 55540 |
mRNA Refseq : | NM_018725 |
Protein Refseq : | NP_061195 |
MIM : | 605458 |
UniProt ID : | Q9NRM6 |
Chromosome Location : | 3p21.1 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; |
Function : | cytokine receptor activity; receptor activity; |
Products Types
◆ Recombinant Protein | ||
IL17RB-01H | Active Recombinant Human IL17RB Protein, hIgG/His-tagged | +Inquiry |
IL17RB-96H | Recombinant Human IL17RB Protein, His (Fc)-Avi-tagged | +Inquiry |
IL17RB-2295H | Recombinant Human IL17RB Protein, His-tagged | +Inquiry |
IL17RB-3369M | Active Recombinant Mouse IL17RB protein(Met1-Gly286), His-tagged | +Inquiry |
IL17RB-990R | Recombinant Rhesus IL17RB Protein (Met1-Gly288), HlgG1 Fc-tagged | +Inquiry |
◆ Lysates | ||
IL17RB-549HCL | Recombinant Human IL17RB cell lysate | +Inquiry |
IL17RB-1115MCL | Recombinant Mouse IL17RB cell lysate | +Inquiry |
IL17RB-871HCL | Recombinant Human IL17RB cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAnimal models, flow cytometry, and tissue-specific knockout strategies uncover IL17RB's involvement in inflammation and cell recruitment.
CRISPR/Cas9, siRNA, and gene editing techniques manipulate IL17RB to investigate its role in autoimmune disease pathogenesis.
Biomarker analysis, patient stratification, and clinical correlation studies investigate IL17RB's association with disease severity.
Co-receptor binding assays, protein-protein interaction studies, and functional rescue experiments reveal IL17RB's interaction partners.
In vitro wound healing assays, fibroblast activation studies, and tissue regeneration models probe IL17RB's contribution to tissue repair.
Blocking antibodies, receptor activation assays, and cytokine profiling reveal IL17RB's impact on immune responses.
Animal models, therapeutic antibody studies, and safety assessments evaluate IL17RB-targeted therapies and clinical translation challenges.
Surface plasmon resonance, ELISA, and competitive binding assays determine IL17RB's affinity for various IL17 family members.
Tumor xenograft models, immune cell infiltration assays, and gene expression analysis explore IL17RB's role in cancer biology.
Phosphorylation assays, gene expression profiling, and co-immunoprecipitation studies elucidate IL17RB-mediated signaling networks.
Customer Reviews (3)
Write a reviewHigh stability.
Good for flow cytometry.
Potent in anti-viral assays.
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