Recombinant Human FGB, His-tagged
Cat.No. : | FGB-74H |
Product Overview : | Recombinant human FGB protein, fused to His-tag at N-terminus, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | FGB also known as fibrinogen beta chain isoform 1 found in humans and most other vertebrates with a similar system of blood coagulation. FGB is the beta component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Form : | Liquid, In 20mM Tris-HCl buffer(pH8.0) containing 10% glycerol |
Molecular Mass : | 40kDa (351aa) |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSDNENVVN EYSSELEKHQ LYIDETVNSN IPTNLRVLRS ILENLRSKIQ KLESDVSAQM EYCRTPCTVS CNIPVVSGKE CEEIIRKGGE TSEMYLIQPD SSVKPYRVYC DMNTENGGWT VIQNRQDGSV DFGRKWDPYK QGFGNVATNT DGKNYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT VQNEANKYQI SVNKYRGTAG NALMDGASQL MGENRTMTIH NGMFFSTYDR DNDGWLTSDP RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG QYTWDMAKHG TDDGVVWMNW KGSWYSMRKM SMKIRPFFPQ Q |
Purity : | >85 % by SDS - PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Gene Name : | FGB fibrinogen beta chain [ Homo sapiens ] |
Official Symbol : | FGB |
Synonyms : | FGB; fibrinogen beta chain; fibrinogen, B beta polypeptide; MGC104327; MGC120405; |
Gene ID : | 2244 |
mRNA Refseq : | NM_001184741 |
Protein Refseq : | NP_001171670 |
MIM : | 134830 |
UniProt ID : | P02675 |
Chromosome Location : | 4q28 |
Pathway : | Blood Clotting Cascade, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; GRB2:SOS provides linkage to MAPK signaling for Intergrins, organism-specific biosystem; |
Function : | chaperone binding; eukaryotic cell surface binding; protein binding, bridging; receptor binding; |
Products Types
◆ Recombinant Protein | ||
FGB-1978R | Recombinant Rat FGB Protein, His (Fc)-Avi-tagged | +Inquiry |
FGB-927P | Recombinant Pig FGB Protein, His-tagged | +Inquiry |
FGB-4088H | Recombinant Human FGB Protein, GST-tagged | +Inquiry |
Fgb-1479R | Recombinant Rat Fgb Protein, His-tagged | +Inquiry |
FGB-2872H | Recombinant Human FGB Protein (Gly45-Gln491), His tagged | +Inquiry |
◆ Native Protein | ||
Fgb -68R | Native Rat Fibrinogen | +Inquiry |
FGB-35D | Native Canine Fibrinogen | +Inquiry |
FGB-46P | Native Porcine Fibrinogen, FITC Labeled | +Inquiry |
◆ Lysates | ||
FGB-6255HCL | Recombinant Human FGB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, congenital fibrinogen disorders, such as afibrinogenemia and hypofibrinogenemia, are genetic disorders characterized by deficient or low FGB protein levels.
Low FGB protein levels can result in impaired blood clotting, leading to an increased risk of bleeding and hemorrhage.
High FGB protein levels can be associated with conditions such as inflammation, infection, and certain cancers.
FGB protein levels can be measured to assess the risk of thrombosis or bleeding in patients with coagulation disorders.
Conditions such as liver disease, DIC (disseminated intravascular coagulation), and certain genetic disorders can lead to decreased FGB protein levels.
Customer Reviews (3)
Write a reviewTheir team of experts has been instrumental in addressing any issues or concerns I have encountered during my experiments.
The FGB Protein boasts remarkable stability, ensuring its integrity is maintained during storage and experimentation.
Equally noteworthy is the remarkable technical support provided by the manufacturer.
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