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Recombinant Human FGB, His-tagged

Cat.No. : FGB-74H
Product Overview : Recombinant human FGB protein, fused to His-tag at N-terminus, was expressed in E.coli.
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  • Gene Information
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Description : FGB also known as fibrinogen beta chain isoform 1 found in humans and most other vertebrates with a similar system of blood coagulation. FGB is the beta component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
Source : E.coli
Species : Human
Tag : His
Form : Liquid, In 20mM Tris-HCl buffer(pH8.0) containing 10% glycerol
Molecular Mass : 40kDa (351aa)
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSDNENVVN EYSSELEKHQ LYIDETVNSN IPTNLRVLRS ILENLRSKIQ KLESDVSAQM EYCRTPCTVS CNIPVVSGKE CEEIIRKGGE TSEMYLIQPD SSVKPYRVYC DMNTENGGWT VIQNRQDGSV DFGRKWDPYK QGFGNVATNT DGKNYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT VQNEANKYQI SVNKYRGTAG NALMDGASQL MGENRTMTIH NGMFFSTYDR DNDGWLTSDP RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG QYTWDMAKHG TDDGVVWMNW KGSWYSMRKM SMKIRPFFPQ Q
Purity : >85 % by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : FGB fibrinogen beta chain [ Homo sapiens ]
Official Symbol : FGB
Synonyms : FGB; fibrinogen beta chain; fibrinogen, B beta polypeptide; MGC104327; MGC120405;
Gene ID : 2244
mRNA Refseq : NM_001184741
Protein Refseq : NP_001171670
MIM : 134830
UniProt ID : P02675
Chromosome Location : 4q28
Pathway : Blood Clotting Cascade, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; GRB2:SOS provides linkage to MAPK signaling for Intergrins, organism-specific biosystem;
Function : chaperone binding; eukaryotic cell surface binding; protein binding, bridging; receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there specific genetic disorders associated with FGB protein abnormalities? 02/21/2023

Yes, congenital fibrinogen disorders, such as afibrinogenemia and hypofibrinogenemia, are genetic disorders characterized by deficient or low FGB protein levels.

What are the potential consequences of low FGB protein levels? 10/07/2022

Low FGB protein levels can result in impaired blood clotting, leading to an increased risk of bleeding and hemorrhage.

How are high FGB protein levels clinically significant? 06/13/2022

High FGB protein levels can be associated with conditions such as inflammation, infection, and certain cancers.

How can FGB protein be used in the diagnosis of coagulation disorders? 06/30/2021

FGB protein levels can be measured to assess the risk of thrombosis or bleeding in patients with coagulation disorders.

What conditions can lead to a decrease in FGB protein levels? 05/22/2017

Conditions such as liver disease, DIC (disseminated intravascular coagulation), and certain genetic disorders can lead to decreased FGB protein levels.

Customer Reviews (3)

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Reviews
03/05/2023

    Their team of experts has been instrumental in addressing any issues or concerns I have encountered during my experiments.

    02/11/2019

      The FGB Protein boasts remarkable stability, ensuring its integrity is maintained during storage and experimentation.

      11/05/2017

        Equally noteworthy is the remarkable technical support provided by the manufacturer.

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