Recombinant Human XIAP Protein, MYC/DDK-tagged

• Cat.No.: XIAP-399H
• Product Overview: Recombinant protein of human X-linked inhibitor of apoptosis (XIAP) with C-MYC/DDK tag was expressed in HEK293T cells.

Specification

• Description: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
• Source: HEK293T
• Species: Human
• Tag: MYC/DDK
• Molecular Mass: 56.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at –80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: XIAP
• Official Symbol: XIAP X-linked inhibitor of apoptosis [ Homo sapiens (human) ]
• Synonyms: XIAP; X-linked inhibitor of apoptosis; API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3; E3 ubiquitin-protein ligase XIAP; IAP-like protein; RING-type E3 ubiquitin transferase XIAP; X-linked IAP; X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase; baculoviral IAP repeat-containing protein 4; inhibitor of apoptosis protein 3; EC 2.3.2.27
• Gene ID: 331
• mRNA Refseq: NM_001167.3
• Protein Refseq: NP_001158.2
• MIM: 300079
• UniProt ID: P98170