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Recombinant Human UGT1A1, MYC/DDK-tagged

Cat.No.: UGT1A1-26H
Product Overview: Recombinant Human UGT1A1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
Source: HEK293 cells
Species: Human
Tag: MYC/DDK
Molecular Mass: 57.1 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name: UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 [ Homo sapiens (human) ]
Official Symbol: UGT1A1
Synonyms: UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1; GNT1; UGT1; UDPGT; UGT1A; HUG-BR1; BILIQTL1; UDPGT 1-1; UDP-glucuronosyltransferase 1-1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; UGT-1A; UGT1*1; UGT1-01; UGT1.1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; bilirubin-specific UDPGT isozyme 1; NP_000454.1; EC 2.4.1.17
Gene ID: 54658
mRNA Refseq: NM_000463
Protein Refseq: NP_000454
MIM: 191740
UniProt ID: P22309
Chromosome Location: 2q37
Pathway: AhR pathway; Chemical carcinogenesis; Defective GSS causes Glutathione synthetase deficiency (GSS deficiency); Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
Function: enzyme binding; enzyme inhibitor activity; NOT glucuronosyltransferase activity; glucuronosyltransferase activity

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