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Recombinant Human MBNL1, MYC/DDK-tagged

Cat.No. : MBNL1-2739H
Product Overview : Recombinant full-length Human MBNL1, transcript variant 1, fused with C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : Muscleblind-like (Drosophila), also known as MBNL1, is a protein that in humans is encoded by the MBNL1 gene. It has been implicated in Myotonic dystrophy and has been shown to autoregulate its transcript. Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins.
Source : HEK293 cells
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 40.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : MBNL1 muscleblind-like splicing regulator 1 [ Homo sapiens ]
Official Symbol : MBNL1
Synonyms : EXP; MBNL; EXP35; EXP40; EXP42; muscleblind-like protein 1; triplet-expansion RNA-binding protein
Gene ID : 4154
mRNA Refseq : NM_021038
Protein Refseq : NP_066368
MIM : 606516
UniProt ID : Q9NR56
Chromosome Location : 3q25
Pathway : Adipogenesis, organism-specific biosystem
Function : RNA binding; double-stranded RNA binding; metal ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does MBNL1 contribute to tissue-specific alternative splicing? 12/07/2022

It contributes to tissue-specific splicing patterns, essential for proper development and function of various tissues.

What are the main functions of MBNL1 in RNA processing? 08/21/2022

MBNL1 regulates alternative splicing, polyadenylation, and localization of mRNAs, impacting gene expression.

What is the role of MBNL1 in the development of muscle tissue? 03/19/2022

MBNL1 plays a key role in muscle development and differentiation, influencing muscle-specific gene expression.

How does MBNL1 dysfunction contribute to myotonic dystrophy? 03/28/2021

In myotonic dystrophy, MBNL1 becomes sequestered by toxic RNA repeats, leading to mis-splicing and muscular dysfunction.

How can MBNL1 activity be modulated for therapeutic purposes? 02/25/2020

Therapeutic modulation of MBNL1 is being explored, focusing on releasing MBNL1 from sequestration and correcting mis-splicing in conditions like myotonic dystrophy.

What are the molecular consequences of MBNL1 sequestration in cells? 11/23/2018

Sequestration of MBNL1 results in altered splicing patterns of numerous genes, contributing to cellular dysfunction.

Are there any known post-translational modifications that regulate MBNL1 activity? 11/07/2018

There is limited information on post-translational modifications regulating MBNL1, necessitating further research.

Customer Reviews (3)

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Reviews
03/24/2022

    Excellent product, fast delivery.

    04/28/2020

      Reliable for my research.

      10/29/2019

        Worked perfectly, highly recommend.

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