Recombinant Human TLR4

Cat.No.: TLR4-887H
Product Overview: Recombinant Human TLR4 (Accession # O00206), fused with , was produced in Mouse myeloma cell line, NS0-derived.
Source: NSO Cells
Species: Human
Predicted N Terminal: Glu24 (TLR4) & Glu17 (MD-2)
Form: Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
Bio-activity: Measured by its ability to inhibit LPS-induced TNF-alpha secretion by PMA-differentiated U937 human histiocytic lymphoma cells.Typically 20 µg/mL of rhTLR4/MD-2 will inhibit >60% of the TNF-alpha secretion induced by 10 ng/mL of LPS.
Molecular Mass: Recombinant Human TLR4 has a calculated MW of 70.6 kDa (TLR4), 19.2 kDa (MD-2). In SDS-PAGE migrates as 95 kDa and 34 kDa, reducing conditions.
Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name: TLR4 toll-like receptor 4 [ Homo sapiens ]
Official Symbol: TLR4
Synonyms: TLR4; toll-like receptor 4; CD284; hToll; TLR 4; homolog of Drosophila toll; TOLL; TLR-4; ARMD10;
Gene ID: 7099
mRNA Refseq: NM_003266
Protein Refseq: NP_003257
MIM:
UniProt ID: O00206
Chromosome Location: 9q33.1

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