"HDAC4" Related Products

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Recombinant Human Histone Deacetylase 4, GST-tagged

Cat. No. : HDAC4-395H
Product Overview : Full Length Human HDAC4– Class IIa, 111kD with GST tag.
Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Source : HDAC4 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.
Purity : Purified, active enzyme.
Purification Procedure : Glutathione Column
Activity : 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
Stability/Shelf-life : >6 months from date of shipment
Buffer Composition : 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol
Storage : –80°C
Gene Name : HDAC4 histone deacetylase 4 [ Homo sapiens ]
Synonyms : HDAC4; HA6116; HD4; HDAC-A; HDACA; KIAA0288; histone deacetylase 4; histone deacetylase A; EC 3.5.1.98.
Gene ID : 9759
mRNA Refseq : NM_006037
Protein Refseq : NP_006028
MIM : 605314
UniProt ID : P56524
Chromosome Location : 2q37.3
Pathway : Gene Expression
Function : DNA binding; histone deacetylase activity; hydrolase activity; A; transcription repressor activity

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