Active Recombinant Human Histone Deacetylase 4, GST-tagged

• Cat.No.: HDAC4-395H
• Product Overview: Full Length Human HDAC4– Class IIa, 111kD with GST tag.

Specification

• Cat. No.: HDAC4-395H
• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
• Source: HDAC4 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.
• Purity: Purified, active enzyme.
• Purification Procedure: Glutathione Column
• Activity: 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
• Stability/Shelf-life: >6 months from date of shipment
• Buffer Composition: 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol
• Storage: –80°C

Gene Information

• Gene Name: HDAC4 histone deacetylase 4 [ Homo sapiens ]
• Synonyms: HDAC4; HA6116; HD4; HDAC-A; HDACA; KIAA0288; histone deacetylase 4; histone deacetylase A; EC 3.5.1.98.
• Gene ID: 9759
• mRNA Refseq: NM_006037
• Protein Refseq: NP_006028
• MIM: 605314
• UniProt ID: P56524
• Chromosome Location: 2q37.3
• Pathway: Gene Expression
• Function: DNA binding; histone deacetylase activity; hydrolase activity; A; transcription repressor activity