Active Recombinant Human Histone Deacetylase 8, GST-tagged

• Cat.No.: HDAC8-399H
• Product Overview: Full Length Human HDAC8 (NM_003883) – Class I, 70kD withGST tag.

Specification

• Cat. No.: HDAC8-399H
• Description: Histone deacetylase 8, also known as HDAC8, is a human gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.
• Source: HDAC8 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.
• Purity: Purified, active enzyme.
• Purification Procedure: Glutathione column
• Activity: 1000 units per vial.1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
• Stability/Shelf-life: >6 months from date of shipment
• Buffer Composition: 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol
• Storage: –80°C

Gene Information

• Gene Name: HDAC8 histone deacetylase 8 [ Homo sapiens ]
• Synonyms: HDAC8; RPD3; HDACL1; histone deacetylase 8; histone deacetylase-like 1; EC 3.5.1.98; HD8.
• Gene ID: 55869
• mRNA Refseq: NM_018486
• Protein Refseq: NP_060956
• MIM: 300269
• UniProt ID: Q9BY41
• Chromosome Location: Xq13
• Pathway: Gene Expression
• Function: histone deacetylase activity; hydrolase activity; transcription factor binding