"IL29" Related Products

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Recombinant Human Interleukin 29 (Interferon, Lambda 1)

Cat. No.: IL29-100H
Product Overview: IL-28A, IL-28B, and IL-29, also named IFN-λ2, IFN-λ3, and IFN-λ1, respectively, are newly identified class II cytokine receptor ligands that are distantly related to members of the IL-10 family and the type I IFN family. The expression of IL-28A, B, and IL-29 is induced by virus infection or double-stranded RNA. All three cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The three proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor β (IL-10 Rβ) and a novel IL-28 receptor α (IL-28 Rα, also known as IFN-λR1).
Sequences of amino acids: PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST
Source: Escherichia Coli.
Formulation: Lyophilized from a 0.2μm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 130mM NaCl.
Purity: >97% by SDS-PAGE and HPLC analyses.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Molecular Weight: 19.8 kDa, a single, non-glycosylated polypeptide chain containing 178 amino acids.
Biological Acivity: Fully biologically active when compared to standard. The ED50 is determined in an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is typically 1-5 ng/ml.
Endotoxin Level: Less than 1EU/μg of rHuIFN-λ1 as determined by LAL method.
Reconstitution: Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.
Storage: This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Gene Name: IL29 interleukin 29 (interferon, lambda 1) [ Homo sapiens ]
Synonyms: IL29; IL-29; IFNL1; IL-28A; IL-28B; IFN-lambda-1; ZCYTO21; interferon-λ2 (IFN-λ2); IFN-λ3; and IFN-λ1; Cytokine ZCYTO21; Interferon lambda-1; interferon, lambda 1; interleukin 29; interleukin 29 (interferon, lambda 1)
Gene ID: 282618
mRNA Refseq: NM_172140
Protein Refseq: NP_742152
MIM: 607403
UniProt ID: Q8IU54
Chromosome Location: 19q13.13
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function: cytokine activity; interleukin-28 receptor binding

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