Recombinant Human Transforming Growth Factor, Beta-induced, 68kDa
Cat.No. : | TGFBI-149H |
Product Overview : | Recombinant human BIGH3 protein was expressed in E. coli and purified by using conventional chromatography techniques(182 aa, 19.9 kDa). |
- Specification
- Gene Information
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Cat. No. : | TGFBI-149H |
Description : | BIGH3, also known as TGFBI and Beta ig-h3, is an extracellular matrix protein induced by transforming growth factor(TGF)-beta 1. BIGH3 protein is involved in cell growth, cell differentiation, wound healing and cell adhesion. In addition, some missense mutations of BIGH3 were identified in families affected with human autosomal dominant corneal dystrophies. BIGH3 gene encodes for a 683 amino-acid protein containing an RGD motif and four internal repeated domains which have highly conserved sequences founded in several species (Fasciclin domain). |
Source : | Escherichia Coli. |
Formulation : | Liquid. In 20 mM Tris-HCl ( pH 8.0) containing 1 mM EDTA, 0.1 mM PMSF, 20% Glycerol. |
Molecular Weight : | 19.9 kDa (182 aa). (Real molecular size on SDS-PAGE will be shift up). |
Purity : | > 95% by SDS – PAGE. |
Concentration : | 0.5 mg/ml (determined by Bradford assay). |
Endotoxin Level : | < 1.0 EU per 1 μg of protein (determined by LAL method). |
Amino acid Sequence : | MGTVMDVLKG DNRFSMLVAA IQSAGLTETL NREGVYTVFA PTNEAFRALP PRERSRLLGD AKELANILKY HIGDEILVSG GIGALVRLKS LQGDKLEVSL KNNVVSVNKE PVAEPDIMAT NGVVHVITNV LQPPANRPQE RGDELADSAL EIFKQASAFS RASQRSVRLA PVYQKLLERM KH |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | TGFBI transforming growth factor, beta-induced, 68kDa [ Homo sapiens ] |
Synonyms : | TGFBI; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; LCD1; kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP; Beta ig-h3; transforming growth factor, beta-induced, 68kDa. |
Gene ID : | 7045 |
mRNA Refseq : | NM_000358 |
Protein Refseq : | NP_000349 |
MIM : | 601692 |
UniProt ID : | Q15582 |
Chromosome Location : | 5q31 |
Function : | integrin binding; protein binding. |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTGFBI protein is essential for maintaining the structure and transparency of the cornea, a clear, dome-shaped outermost layer of the eye.
Mutations or abnormalities in the TGFBI protein can lead to various corneal dystrophies, which are inherited eye disorders that affect vision.
In severe cases, these dystrophies can lead to vision impairment or blindness. Early diagnosis, appropriate treatment, and regular eye care can help prevent or delay vision loss.
TGFBI mutations are typically diagnosed through genetic testing, corneal examinations, and medical history.
Customer Reviews (3)
Write a reviewHighly recommended and known for its outstanding performance in ELISA, the TGFBI protein is a top choice for researchers in protein electron microscopy structure analysis.
By utilizing the TGFBI protein, researchers can confidently explore the intricate details of protein structures and gain invaluable insights into their functionality.
Its exceptional properties and reliable results make it a valuable tool in various experimental applications.
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