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Recombinant Human Transforming Growth Factor, Beta-induced, 68kDa

Cat.No. : TGFBI-149H
Product Overview : Recombinant human BIGH3 protein was expressed in E. coli and purified by using conventional chromatography techniques(182 aa, 19.9 kDa).
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Cat. No. : TGFBI-149H
Description : BIGH3, also known as TGFBI and Beta ig-h3, is an extracellular matrix protein induced by transforming growth factor(TGF)-beta 1. BIGH3 protein is involved in cell growth, cell differentiation, wound healing and cell adhesion. In addition, some missense mutations of BIGH3 were identified in families affected with human autosomal dominant corneal dystrophies. BIGH3 gene encodes for a 683 amino-acid protein containing an RGD motif and four internal repeated domains which have highly conserved sequences founded in several species (Fasciclin domain).
Source : Escherichia Coli.
Formulation : Liquid. In 20 mM Tris-HCl ( pH 8.0) containing 1 mM EDTA, 0.1 mM PMSF, 20% Glycerol.
Molecular Weight : 19.9 kDa (182 aa). (Real molecular size on SDS-PAGE will be shift up).
Purity : > 95% by SDS – PAGE.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Endotoxin Level : < 1.0 EU per 1 μg of protein (determined by LAL method).
Amino acid Sequence : MGTVMDVLKG DNRFSMLVAA IQSAGLTETL NREGVYTVFA PTNEAFRALP PRERSRLLGD AKELANILKY HIGDEILVSG GIGALVRLKS LQGDKLEVSL KNNVVSVNKE PVAEPDIMAT NGVVHVITNV LQPPANRPQE RGDELADSAL EIFKQASAFS RASQRSVRLA PVYQKLLERM KH
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : TGFBI transforming growth factor, beta-induced, 68kDa [ Homo sapiens ]
Synonyms : TGFBI; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; LCD1; kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP; Beta ig-h3; transforming growth factor, beta-induced, 68kDa.
Gene ID : 7045
mRNA Refseq : NM_000358
Protein Refseq : NP_000349
MIM : 601692
UniProt ID : Q15582
Chromosome Location : 5q31
Function : integrin binding; protein binding.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does TGFBI protein play a role in corneal health? 09/10/2022

TGFBI protein is essential for maintaining the structure and transparency of the cornea, a clear, dome-shaped outermost layer of the eye.

What are the clinical implications of TGFBI protein mutations or abnormalities? 10/07/2021

Mutations or abnormalities in the TGFBI protein can lead to various corneal dystrophies, which are inherited eye disorders that affect vision.

Can TGFBI-related corneal dystrophies lead to blindness, and if so, how can this be prevented? 06/01/2021

In severe cases, these dystrophies can lead to vision impairment or blindness. Early diagnosis, appropriate treatment, and regular eye care can help prevent or delay vision loss.

What are some common corneal dystrophies associated with TGFBI protein mutations? 05/21/2018

How are TGFBI protein mutations diagnosed in clinical practice? 07/19/2016

TGFBI mutations are typically diagnosed through genetic testing, corneal examinations, and medical history.

Customer Reviews (3)

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Reviews
08/15/2022

    Highly recommended and known for its outstanding performance in ELISA, the TGFBI protein is a top choice for researchers in protein electron microscopy structure analysis.

    03/30/2020

      By utilizing the TGFBI protein, researchers can confidently explore the intricate details of protein structures and gain invaluable insights into their functionality.

      12/09/2016

        Its exceptional properties and reliable results make it a valuable tool in various experimental applications.

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