Recombinant Human Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase)
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| Cat. No. : | UCHL1-181H |
| Product Overview : | Recombinant PGP9.5 protein was expressed in E.coli and purified by using conventional chromatography techniques (223 aa, 24.8 kDa). |
| Description : | PGP9.5/UCH-L1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. PGP9.5 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. PGP9.5 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson"s disease susceptibility. |
| Source : | Escherichia Coli. |
| Formulation : | Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 2 mM EDTA. |
| Molecular Weight : | 24.8 kDa (223 aa) (Real molecular weight on SDS-PAGE will be shift up). |
| Purity : | > 95% by SDS – PAGE. |
| Concentration : | 1 mg/ml (determined by Bradford assay). |
| Amino acid Sequence : | MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE TEKMSPEDRA KCFEKNEAIQ AAHDAVAQEG QCRVDDKVNF HFILFNNVDG HLYELDGRMP FPVNHGASSE DTLLKDAAKV CREFTEREQG EVRFSAVALC KAA |
| Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
| PDBrendering based on 2etl.Available structures:2etl. : |
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| Gene Name : | UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) [ Homo sapiens ] |
| Synonyms : | UCHL1; PARK5; PGP9.5; Uch-L1; UCH-L1; EC 3.4.19.12, EC 6.-.-.-; Neuron cytoplasmic protein 9.5; Ubiquitin thioesterase L1; ubiquitin C-terminal esterase L1; ubiquitin carboxyl-terminal esterase L1; ubiquitin thiolesterase L1; Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin carboxy-terminal hydrolase L1; Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1); EC 3.1.2.15; ubiquitin thiolesterase; ubiquitin carboxy-terminal esterase; isopeptidase; isopeptidase T; ubiquitin C-terminal hydrolase; ubiquitin carboxy-terminal hydrolase; ubiquitin-C-terminal-thiolester hydrolase; ubiquitin-C-terminal-thioester hydrolase. |
| Gene ID : | 7345 |
| mRNA Refseq : | NM_004181 |
| Protein Refseq : | NP_004172 |
| MIM : | 191342 |
| UniProt ID : | P09936 |
| Chromosome Location : | 4p14 |
| Pathway : | Neurodegenerative Disorders; Parkinson"s disease. |
| Function : | cysteine-type endopeptidase activity; ligase activity; omega peptidase activity; peptidase activity; protein binding; ubiquitin binding; ubiquitin thiolesterase activity. |
◆ Recombinant Protein
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| UCHL1-35H | Recombinant Human UCHL1 Protein, His-tagged | +Inquiry |
| Uchl1-611M | Recombinant Mouse Uchl1 Protein, His-tagged | +Inquiry |
| UCHL1-6418R | Recombinant Rat UCHL1 Protein | +Inquiry |
| UCHL1-49H | Recombinant Human UCHL1, GST-tagged | +Inquiry |
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◆ Lysates
| UCHL1-535HCL | Recombinant Human UCHL1 293 Cell Lysate | +Inquiry |
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