Cat. No.: | UCHL1-181H |
Product Overview: | Recombinant PGP9.5 protein was expressed in E.coli and purified by using conventional chromatography techniques (223 aa, 24.8 kDa). |
Description: | PGP9.5/UCH-L1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. PGP9.5 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. PGP9.5 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson"s disease susceptibility. |
Source: | Escherichia Coli. |
Formulation: | Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 2 mM EDTA. |
Molecular Weight: | 24.8 kDa (223 aa) (Real molecular weight on SDS-PAGE will be shift up). |
Purity: | > 95% by SDS – PAGE. |
Concentration: | 1 mg/ml (determined by Bradford assay). |
Amino acid Sequence: | MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE TEKMSPEDRA KCFEKNEAIQ AAHDAVAQEG QCRVDDKVNF HFILFNNVDG HLYELDGRMP FPVNHGASSE DTLLKDAAKV CREFTEREQG EVRFSAVALC KAA |
Storage: | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name: | UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) [ Homo sapiens ] |
Synonyms: | UCHL1; PARK5; PGP9.5; Uch-L1; UCH-L1; EC 3.4.19.12, EC 6.-.-.-; Neuron cytoplasmic protein 9.5; Ubiquitin thioesterase L1; ubiquitin C-terminal esterase L1; ubiquitin carboxyl-terminal esterase L1; ubiquitin thiolesterase L1; Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin carboxy-terminal hydrolase L1; Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1); EC 3.1.2.15; ubiquitin thiolesterase; ubiquitin carboxy-terminal esterase; isopeptidase; isopeptidase T; ubiquitin C-terminal hydrolase; ubiquitin carboxy-terminal hydrolase; ubiquitin-C-terminal-thiolester hydrolase; ubiquitin-C-terminal-thioester hydrolase. |
Gene ID: | 7345 |
mRNA Refseq: | NM_004181 |
Protein Refseq: | NP_004172 |
MIM: | 191342 |
UniProt ID: | P09936 |
Chromosome Location: | 4p14 |
Pathway: | Neurodegenerative Disorders; Parkinson"s disease. |
Function: | cysteine-type endopeptidase activity; ligase activity; omega peptidase activity; peptidase activity; protein binding; ubiquitin binding; ubiquitin thiolesterase activity. |
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