Recombinant Human Tight Junction Protein 1 (Zona Occludens 1)

• Cat.No.: TJP1-239H
• Product Overview: Recombinant Human ZO-1 protein expressed inE.coliencodes 334-634 amino acids and has a molecular mass of 61 kDa through SDS-PAGE analysis.

Specification

• Cat. No.: TJP1-239H
• Description: ZO-1 is a peripheral membrane protein that is associated with tight junctions which are found on the cytoplasmic surface of epitheliual and endothelial cell membrane. ZO-1 has a MW of 225kDa and is found in two isoforms that differ by the presence or absence of an 80 amino acid region known as 'motif-a'.
• Source: Recombinant Human ZO-1 protein encoding 334-634 amino acids expressed inE.coli.
• Formulaiton: Recombinant Human ZO-1 protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
• Application and suggested dilutions: •ELISA •Inhibition Assays •Western Blotting
• Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 61 kDa.
• Storage & stability: Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.

Gene Information

• Gene Name: TJP1 tight junction protein 1 (zona occludens 1) [ Homo sapiens ]
• Synonyms: TJP1; tight junction protein 1 (zona occludens 1); ZO-1; MGC133289; DKFZp686M05161; zonula occludens 1 protein; tight junction protein ZO-1; 3` partial; zona occludens 1;Zonula occludens protein 1; Tight junction protein 1; OTTHUMP00000174520; zonula occludens 1 protein
• Gene ID: 7082
• mRNA Refseq: NM_003257
• Protein Refseq: NP_003248
• MIM: 601009
• UniProt ID: Q07157
• Chromosome Location: 15q13
• Pathway: Adherens junction; Epithelial cell signaling in Helicobacter pylori infection; Gap junction; Tight junction; Vibrio cholerae infection; Apoptosis; Gap junction trafficking and regulation
• Function: protein binding