Recombinant Human Progesterone Receptor


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Recombinant Human Progesterone Receptor

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Cat. No. : PGR-182H
Product Overview : Recombinant Human progesterone receptor protein expressed inE.coliencodes 412-562 amino acids and has a molecular mass of 43 kDa.
Description : The progesterone receptor (PgR) is an estrogen-regulated protein. It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival. PgR has proved superior to ER as a prognostic indicator in some studies.
Source : E.coli.
Formulation : Recombinant Human PGR at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Application And Suggested Dilutions : •ELISA •Inhibition Assays •Western Blotting.
Characterization : On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 43 kDa.
Activity : Not known.
Storage & Stability : Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
PDB rendering based on 1a28. :

Gene Name : PGR progesterone receptor [ Homo sapiens ]
Synonyms : PGR; progesterone receptor; PR; NR3C3; Nuclear receptor subfamily 3 group C member 3
Gene ID : 5241
mRNA Refseq : NM_000926
Protein Refseq : NP_000917
MIM : 607311
UniProt ID : P06401
Chromosome Location : 11q22-q23
Function : metal ion binding; protein N-terminus binding; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; transcription factor activity; zinc ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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