"S100P" Related Products

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Recombinant Human S100 Calcium Binding Protein P

Cat. No.: S100P-205H
Product Overview: Recombinant Human S100P contains 95 amino acids and has a molecular mass of 10.4 kDa, produced inE.Coli.
Description: S100P was originally described as a placental protein of 95 amino acid residues shares about 50% sequence identity with the brain S100 proteins alpha and beta. S100 proteins are small dimeric members of the EF-hand superfamily of Ca(2+) binding proteins thought to participate in mediating intracellular Ca(2+) signals by binding to and thereby regulating target proteins in a Ca(2+)-dependent manner. S100P is dysregulated in the androgen-independent prostate cancer cell lines LNCaP-R, DU145, and PC3 and may play a role in the etiology of prostate cancer. In NIH3T3 cells, the expression of S100P led to the presence of S100P in the culture medium, increased cellular proliferation, and enhanced survival following detachment from the culture substrate or after exposure to the chemotherapeutic agent 5-flurouracil. The proliferation and survival effects of S100P expression were duplicated in a time- and concentrationdependent manner by extracellular addition of purified S100P to wild-type NIH3T3 cells and correlated with the activation of Erks and NFB.
Source: Escherichia Coli.
Sequences Of Amino Acids: MTELEAAMGM IIDVFSRYSG SEGSTQTLTK GELKVLMEKE LPGFLQSGKD KDAVDKLLKD LDANGDAQVD FSEFIVFVAA ITSACHKYFE KAGLK.
Specificity: The recombinant human S100P is 100% homologous with the human S100P.
Purity: >95% (SDS-PAGE analyzed).
Formulation: Sterile filtered and lyophilized from 0.5 mg/ml in 0.05M Phosphate buffer pH7.2, 0.1M NaCl.
Reconstitution: Add 0.2 ml of deionized H2O and let the lyophilized pellet dissolve completely.
Stability/Shelf Life: The lyophilized protein remains stable until the expiry date when stored at -20°C.
Applications: Western blotting.
Storage: Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Gene Name: S100P S100 calcium binding protein P [ Homo sapiens ]
Synonyms: S100P; MIG9; S100E; S100 calcium binding protein P; migration-inducing gene 9; S100 calcium-binding protein P; Protein S100-P; OTTHUMP00000115574
Gene ID: 6286
mRNA Refseq: NM_005980
Protein Refseq: P_005971
MIM: 600614
UniProt ID: P25815
Chromosome Location: 4p16
Function: calcium ion binding; calcium-dependent protein binding; magnesium ion binding

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