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Recombinant Human TROVE domain family, member 2

Cat. No.: TROVE2-197H
Product Overview: Recombinant Human RO-60 produced inE.Coliis a single, non-glycosylated, polypeptide chain. The rHuRO-60 has a molecular mass of 60kDa. The rHuRO-60 is purified by proprietary chromatographic techniques.
Description: Calreticulin is a multifunctional protein that binds Ca2+ ions (a second messenger molecule in signal transduction), rendering it inactive. The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal (see inositol triphosphate). Calreticulin is located in storage compartments associated with the endoplasmic reticulum.
Source: Escherichia Coli.
Physical Appearance: Sterile Filtered clear solution.
Formulation: The protein solution (0.67mg/ml) contains 6M Urea, 500mM NaCl and 10mM Tris pH8.0.
Purity: Greater than 90.0% as determined by both: (a) Analysis by RP-HPLC. (b) Anion-exchange FPLC. (c) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
Dimers And Aggregates: Less than 1% as determined by silver-stained SDS-PAGE gel analysis.
Endotoxin: Less than 0.1 ng/µg (IEU/µg) of rHuRO-60.
Protein Content: Protein quantitation was carried out by using 0.5 - 2.0 mg/ml Bradford assay vs. BSA.
Stability: Lyophilized rHuRO-60 although stable at 4°Cfor 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Gene Name: TROVE2 TROVE domain family, member 2 [ Homo sapiens ]
Synonyms: TROVE2;TROVE domain family, member 2; RO60; SSA2; TROVE2; TROVE domain family, member 2; Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein autoantigen SS-A/Ro);60 kDa SS-A/Ro ribonucleoprotein; 60 kDa ribonucleoprotein Ro; 60 kDa Ro protein RoRNP; 60 kDa Ro protein; Ro 60 kDa autoantigen; TROVE domain family member 2; TROVE domain family, member 2; bA101E13.2 (Sjogren syndrome antigen A2 (60kD ribonucleoprotein autoantigen SS-A/Ro)); Sjoegren syndrome type A antigen; SS-A; Sjoegren syndrome antigen A2; Sjogren syndrome antigen A2 (60kD, ribonucleoproteinautoantigen SS-A/Ro); Sjogren syndrome antigen A2 (60kDa, ribonucleoproteinautoantigen SS-A/Ro); OTTHUMP00000033759; OTTHUMP00000033760; OTTHUMP00000033764; RoRNP; gastric cancer multi-drug resistance protein; ribonucleoprotein autoantigen SS-A/Ro
Gene ID: 6738
mRNA Refseq: NM_001042369
Protein Refseq: NP_001035828
MIM: 600063
UniProt ID: P10155
Chromosome Location: 1q31
Pathway: Systemic lupus erythematosus
Function: RNA binding;protein binding

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