Recombinant Human IFNA2

• Cat.No.: IFNA2-24H
• Product Overview: Recombinant Human Albumin/HSA fusion Interferon α-2b produced in P. pastoris is a single non-glycosylated polypeptide chain with a molecular mass of 85.7 kD.

Specification

• Description: At least 23 different variants of Interferon-α are known. The individual proteins have molecular masses between 19-26 kD and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-α subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-α subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxyl-terminal end.
• Source: P. pastoris
• Species: Human
• Form: Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.2
• Molecular Mass: 85.7 kD
• AA Sequence: DAHKSEVAHRFKDLGEENFKALVLI AFAQYLQQCPFEDHVKLVNEVTEFA KTCVADESAENCDKS LHTLFGDKLCTVATLRETYGEMADC CAKQEPERNECFLQHKDDNPNLPRL VRPEVDVMCTAFHDN EETFLKKYLYEIARRHPYFYAPELL FFAKRYKAAFTECCQAADKAACLLP KLDELRDEGKASSAK QRLKCASLQKFGERAFKAWAVARLS QRFPKAEFAEVSKLVTDLTKVHTEC CHGDLLECADDRADL AKYICENQDSISSKLKECCEKPLLE KSHCIAEVENDEMPADLPSLAADFV ESKDVCKNYAEAKDV FLGMFLYEYARRHPDYSVVLLLRLA KTYETTLEKCCAAADPHECYAKVFD EFKPLVEEPQNLIKQ NCELFEQLGEYKFQNALLVRYTKKV PQVSTPTLVEVSRNLGKVGSKCCKH PEAKRMPCAEDYLSV VLNQLCVLHEKTPVSDRVTKCCTES LVNRRPCFSALEVDETYVPKEFNAE TFTFHADICTLSEKE RQIKKQTALVELVKHKPKATKEQLK AVMDDFAAFVEKCCKADDKETCFAE EGKKLVAASQAALGL CDLPQTHSLGSRRTLMLLAQMRRIS LFSCLKDRHDFGFPQEEFGNQFQKA ETIPVLHEMIQQIFN LFSTKDSSAAWDETLLDKFYTELYQ QLNDLEACVIQGVGVTETPLMKEDS ILAVRKYFQRITLYL KEKKYSPCAWEVVRAEIMRSFSLST NLQESLRSKE
• Endotoxin: Less than 0.1 ng/μg (1 IEU/μg).
• Purity: Greater than 98% as determined by SEC-HPLC and reducing SDS-PAGE.
• Storage: Lyophilized protein should be stored at Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at
• Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 1X PBS.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Gene Information

• Gene Name: IFNA2 interferon, alpha 2 [ Homo sapiens ]
• Official Symbol: IFNA2
• Synonyms: IFNA2; interferon, alpha 2; interferon alpha-2; alpha 2a interferon; IFN alphaA; IFNA; interferon alpha 2b; interferon alpha A; leIF A; IFN-alpha-2; alpha-2a interferon; INFA2; IFNA2B; IFN-alphaA; MGC125764; MGC125765
• Gene ID: 3440
• mRNA Refseq: NM_000605
• Protein Refseq: NP_000596
• MIM: 147562
• UniProt ID: P01563
• Chromosome Location: 9p22
• Pathway: Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem
• Function: cytokine activity; interferon-alpha/beta receptor binding; protein binding