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Recombinant Human Interleukin 4 Receptor, 148aa, Fc Chimera

Cat. No.: IL4R-123H
Product Overview: Recombinant Human interleukin 4 receptor encoding the signal peptide and extracellular domain of human Interleukin 4 receptor alpha chain (IL-4R alpha; IL-4Ra) (aa 1-172) was expressed in modifiedhuman 293 cells. Itwas fused to the Fc region of human IgG1 (aa 93-330).
Description: IL-4R alpha is an 825 amino acid glycoprotein and contains 4 potential N-glycosylation sites. Apollo IL-4R alpha is produced as an ECD-Fc fusion protein with the aim of enhancing its activity.
Source: Human 293 cells.
Amino Acid Sequence: MKVLQEPTCV SDYMSISTCE WKMNGPTNC STELRLLYQLV FLLSEAHTCIP ENNGGAGCV C HLLMDDVVS ADNYTLDLW AGQQLLW KGSFKPS EHVKPRA PG NLTVH TNVSDTLL LT WSNPY PPDNYLY NHLTYAV NIWSEND PADFTRA K VDKKVE PKSCDKT HTCPPCP APELLGG PS VFLFPP KPKDTLMI SRTPEVTC VVVDVSHE DPEVKFNW YVDGVEVH NAKTKPRE EQ YN STY RVVSVLT VLHQDW LN GKEY KCRVSN KALPAPIE KTISKAKGQ PREPQVYTL PPSRDELTK NQ V SLTCLV KGFYPSDIA VEWESNGQ PENNYKTT PPVLDSDG SFFLYSKLT VD KS RWQ QGNV FSCS VMHEALHNHYTQKSLSLSPGK.
Molecular Mass: Under reducing conditions IL-4R alpha (148aa) – Fc Chimera migrates as a band between 50 and 65 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation. This compares with the unmodified IL-4R alpha - Fc that has a predicted monomeric molecular mass of 42.5 kDa.
PI: IL-4R alpha (148aa) – Fc Chimeraseparates into a number of isoforms with a pI between 5.0 and 6.6 in 2D PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified IL-4R alpha-Fc Chimera that has a predicted pI of 6.1.
% Carbohydrate: Purified IL-4R alpha (148aa) - Fc Chimera consists of 15-35% carbohydrate by weight.
Glycosylation: IL-4R alpha (148aa) – FcChimera has N-linked oligosaccharides and may have O-linked oligosaccharides.
Purity: >95%, as determined by SDS-PAGE and visualized by silver stain.
Formulation: When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Reconstitution: It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Storage: Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Gene Name: IL4R interleukin 4 receptor [ Homo sapiens ]
Synonyms: IL4R; interleukin 4 receptor; CD124; IL4RA; OTTHUMP00000122506; interleukin 4 receptor alpha chain; interleukin-4 receptor alpha chain; IL-4R-alpha; CD124 antigen
Gene ID: 3566
mRNA Refseq: NM_000418
Protein Refseq: NP_000409
MIM: 147781
UniProt ID: P24394
Chromosome Location: 16p12.1-p11.2
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Hematopoietic cell lineage
Function: interleukin-4 receptor activity; receptor activity; protein binding; receptor signaling protein activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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