Recombinant Human Tyrosinase (Oculocutaneous Albinism IA)
Cat.No. : | TYR-222H |
Product Overview : | Recombinant Human Tyrosinase was produced inE. Coli. |
- Specification
- Gene Information
- Related Products
Cat. No. : | TYR-222H |
Description : | Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway. Tyrosinase and melan A are the most commonly expressed melanoma markers and are found in approximately 80 to 100 per cent of cases. This antibody is of help in the identification of melanocytic tumors. |
Source : | E. Coli. |
Formulation : | Recombinant Human Tyrosinase protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol without BSA and Sodium Azide. |
Solubility : | It is recommended to dilute the recombinant material in sterile 18 MO-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Stability : | Store undiluted at -20°C to -80 °C. Stable up to 12 months. Please avoid freeze-thaw cycles. |
Purity : | On SDS-PAGE commassie blue stained gel, the recombinant protein shows a band at 64kda including GST. |
Gene Name : | TYR tyrosinase (oculocutaneous albinism IA) [ Homo sapiens ] |
Synonyms : | TYR; tyrosinase (oculocutaneous albinism IA); OCA1A; OCAIA; SHEP3; Tyrosinase;EC1.14.18.1; Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB |
Gene ID : | 7299 |
mRNA Refseq : | NM_000372 |
Protein Refseq : | NP_000363 |
MIM : | 606933 |
UniProt ID : | P14679 |
Chromosome Location : | 11q14-q21 |
Pathway : | Betalain biosynthesis; Biosynthesis of alkaloids derived from shikimate pathway; Isoquinoline alkaloid biosynthesis; Melanogenesis; Metabolic pathways; Riboflavin metabolism; Tyrosine metabolism |
Function : | copper ion binding; metal ion binding; monooxygenase activity; monophenol monooxygenase activity; protein binding; protein heterodimerization activity |
Products Types
◆ Recombinant Protein | ||
TYR-2965H | Recombinant Human TYR Protein, MYC/DDK-tagged | +Inquiry |
Tyr-6757M | Recombinant Mouse Tyr Protein, Myc/DDK-tagged | +Inquiry |
TYR-1551H | Recombinant Human TYR Protein (19-377 aa), His-tagged | +Inquiry |
TYR-238H | Recombinant Human TYR Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
TYR-9798M | Recombinant Mouse TYR Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
TYR-1869HCL | Recombinant Human TYR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0836 | Tyrosine Colorimetric Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionThere are no drugs that directly increase TYR protein levels, but there are drugs that can treat diseases that cause low TYR protein levels.
This protein may play a role in skin aging because it is involved in the production and metabolism of melanin. However, skin aging is also related to other factors, such as genetics, environment, etc.
Some whitening products claim to inhibit the TYR protein, thereby reducing the production of melanin. However, the efficacy and safety of these products have yet to be proven.
It is difficult to directly increase the level of TYR protein through diet because TYR protein is mainly genetically determined. However, the presence of copper in the diet can promote the function of the TYR protein.
TYR is not directly related to tanning. Tanning is a process by which skin cells produce melanin due to ultraviolet rays.
TYR protein may be involved in the occurrence and progression of skin cancer because it is involved in the production and metabolism of melanin.
Customer Reviews (3)
Write a reviewRepeatability is good, the results of multiple experiments are highly consistent, and the repeatability is particularly good.
High solubility, can be dissolved in various types of reagents, easy to operate.
Not easy to inactivate, tried a variety of experimental conditions, still active.
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