Recombinant Human Tyrosinase (Oculocutaneous Albinism IA)

• Cat.No.: TYR-222H
• Product Overview: Recombinant Human Tyrosinase was produced inE. Coli.

Specification

• Cat. No.: TYR-222H
• Description: Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway. Tyrosinase and melan A are the most commonly expressed melanoma markers and are found in approximately 80 to 100 per cent of cases. This antibody is of help in the identification of melanocytic tumors.
• Source: E. Coli.
• Formulation: Recombinant Human Tyrosinase protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol without BSA and Sodium Azide.
• Solubility: It is recommended to dilute the recombinant material in sterile 18 MO-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
• Stability: Store undiluted at -20°C to -80 °C. Stable up to 12 months. Please avoid freeze-thaw cycles.
• Purity: On SDS-PAGE commassie blue stained gel, the recombinant protein shows a band at 64kda including GST.

Gene Information

• Gene Name: TYR tyrosinase (oculocutaneous albinism IA) [ Homo sapiens ]
• Synonyms: TYR; tyrosinase (oculocutaneous albinism IA); OCA1A; OCAIA; SHEP3; Tyrosinase;EC1.14.18.1; Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB
• Gene ID: 7299
• mRNA Refseq: NM_000372
• Protein Refseq: NP_000363
• MIM: 606933
• UniProt ID: P14679
• Chromosome Location: 11q14-q21
• Pathway: Betalain biosynthesis; Biosynthesis of alkaloids derived from shikimate pathway; Isoquinoline alkaloid biosynthesis; Melanogenesis; Metabolic pathways; Riboflavin metabolism; Tyrosine metabolism
• Function: copper ion binding; metal ion binding; monooxygenase activity; monophenol monooxygenase activity; protein binding; protein heterodimerization activity