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Recombinant Human SERPINA1

Cat.No. : SERPINA1-518H
Product Overview : Recombinant Antitrypsin protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 44.4 kDa (395 aa).
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Cat. No. : SERPINA1-518H
Description : Alpha 1 proteinase inhibitor (Antitrypsin) has a characteristicsecondary structureof beta sheets and alpha helices. That is a serum glycoprotein synthesized in the liver. It acts as an elastase inhibitor, primarily inhibiting neutrophil elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. Also Increase in Antitrypsin occurs as an acute phase response to tissue necrosis and inflammation. Serum level of Antitrypsin is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
Source : E.coli.
Amino Acid Sequence : MEDPQGDAAQ KTDTSHHDQD HPTFNKITPN LAEFAFSLYR QLAHQSNSTN IFFSPVSIAT AFAMLSLGTK ADTHDEILEG LNFNLTEIPE AQIHEGFQEL LRTLNQPDSQ LQLTTGNGLF LSEGLKLVDK FLEDVKKLYH SEAFTVNFGD TEEAKKQIND YVEKGTQGKI VDLVKELDRD TVFALVNYIF FKGKWERPFE VKDTEEEDFH VDQVTTVKVP MMKRLGMFNI QHCKKLSSWV LLMKYLGNAT AIFFLPDEGK LQHLENELTH DIITKFLENE DRRSASLHLP KLSITGTYDL KSVLGQLGIT KVFSNGADLS GVTEEAPLKL SKAVHKAVLT IDEKGTEAAG AMFLEAIPMS IPPEVKFNKP FVFLMIDQNT KSPLFMGKVV NPTQK.
Form : Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 1 mM DTT, 2 mM EDTA, 10% glycerol.
Purity : > 90% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 [ Homo sapiens ]
Synonyms : SERPINA1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; PI; A1A; AAT; PI1; A1AT; MGC9222; PRO2275; MGC23330; serine proteinase inhibitor, clade A, member 1; OTTHUMP00000197150; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin serine (or cysteine) proteinase inhibitor, clade A, member 1
Gene ID : 5265
mRNA Refseq : NM_000295
Protein Refseq : NP_000286
MIM : 107400
UniProt ID : P01009
Chromosome Location : 14q32.1
Pathway : Complement and coagulation cascades; Hemostasis
Function : peptidase activity; peptidase inhibitor activity; protease binding; protein binding; serine-type endopeptidase inhibitor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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